27. Interaction of the Fibrinolytic, Coagulation, and Kinin Systems: Disseminated Intravascular Coagulation; and Related Pathology Flashcards
1
Q
- D-Dimer formation is the result of the action of plas-min on:
a.Fibrin monomer
b.Fibrinogen
c.Cross-linked fibrin
d.FDPs
A
c.Cross-linked fibrin
2
Q
- Inactivation of factors Va and VIIIa is caused by:
a. Thrombin
b. Protein S
c.t-PA
d.Activated protein C
A
d.Activated protein C
3
Q
- In primary fibrinolysis, which of the following labora-tory tests will be abnormal?
a.Platelet count
b.D-Dimer level
c.Fibrinopeptide A level
d.Thrombin time
A
d.Thrombin time
4
Q
4.In DIC presenting clinically as a hypercoagulable state,it is not unusual for which of the following coagulation times to be paradoxically shortened?
a.Reptilase time
b. Euglobulin lysis time
c.APTT
d.Thrombin time
A
c.APTT
5
Q
5.The primary inhibitor of the fibrinolytic system is:
a.Antithrombin III
b.a2-Antiplasmin
c.Protein C
d. α2-Macroglobulin
A
b.a2-Antiplasmin
6
Q
6.The primary tissue source for tissue plasminogen activa-tor(tPA)is:
a.Neutrophils
b.Mast cells
c.Endothelial cells
d.Pluripotential stem cells
A
c.Endothelial cells
7
Q
- DIC associated with malignancy can be due to:
a. Tumor tissue factor-like activity
b. Factor X activation by tumor cysteine protease activity
c. Endothelial cell disruption by tumor invasion
d.All of the above
A
d.All of the above
8
Q
- Prothrombin fragment F1.2 is formed by the action of which protease action on prothrombin:
a. Plasmin
b.TAFI
c.Factor VIIa
d.Factor Xa
A
d.Factor Xa
9
Q
- Clinical conditions associated with DIC include:
a.Snake bites
b.Sepsis
c. Acute promyelocytic leukemia
d.All of the above
A
d.All of the above
10
Q
- Which of the following laboratory tests is diagnostic of DIC:
a. Prolonged thrombin time
b.Elevated D-dimers
c.Hypofibrinogenemia
d. None of the above
A
d. None of the above
