25. Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Question 1

1.A patient presents with a platelet count of 212 x10°/L and a bleeding time of 12 minutes.These results most probably suggest:
a.Decreased platelet production
b.Defective platelet function
c.Increased platelet prodaction
d.Increased plateler destruction

Answer 1

b.Defective platelet function

Question 2

2. Which of the following clinical manifestations is most characteristic of a platelet disorder:
   a. Mucosal bleeding
   b.Hemarthrosis
   c.Retroperitoneal hemorrhage
   d. Deep muscle hematomas

Answer 2

a. Mucosal bleeding

Question 3

3.Which of the following is not characteristic of Bernard-Soulier syndrome?
a.Prolonged bleeding time
b. Absent platelet aggregation in response to bovine vWF or human vWF plus ristocetin
c.Abnormal platelet aggregation in response to ADP,collagen,and epinephrine
d. Abnormality in platelet membrane GPIb/IX

Answer 3

c.Abnormal platelet aggregation in response to ADP,collagen,and epinephrine

Question 4

4.Which of the following is not characteristic of Glanzmann’s thrombasthenia?
a.Prolonged bleeding time
b. Giant platelets with thrombocytopenia
c.Absent platelet aggregation in response to ADP,thrombin, collagen, and epinephrine
d. Normal platelet aggregation toristocetin and bovine vWF

Answer 4

b. Giant platelets with thrombocytopenia

Question 5

5.Which of the following statements is not true regarding acute idiopathic thrombocytopenia (ITP)?

a.Thrombocytopenia occurs following a viral infection.
b.Spontaneous remissions are common.
c. It is found primarily in young children.
d.Platelet counts are generally higher than in chronic ITP.

Answer 5

d.Platelet counts are generally higher than in chronic ITP.

Question 6

6.Thrombocytopenia, fever, renal disease, microangio-pathic hemolytic anemia, and neurologic complications are hallmark characteristics of:

a. Hemolytic uremic syndrome (HUS)
b.Disseminated intravascular coagulation (DIC)
c. Thrombotic thrombocytopenic purpura (TTP)
d. Idiopatbic thrombocytopenic purpura (ITP)

Answer 6

c. Thrombotic thrombocytopenic purpura (TTP)

Question 7

7.What disorders are classically associated with thrombocytosis?
a.Myeloproliferative syndromes
b. Autoimmune disorders
c.Immunodeficiency syndrome(HIV)
d.Renal disease

Answer 7

a.Myeloproliferative syndromes

Question 8

8.Which of the following is not an inherited vascular defect?
a. Ehlers-Danlos syndrome
b.Marfan syndrome
c.Amyloidosis
d. Giant hemangiomas

Answer 8

c.Amyloidosis

Question 9

9.Which conditionis classified as nonimmunologic throm-bocytopenia?
a. DIC
b.ITP
c.Storage pool defects
d. Post-transfusion purpura

Answer 9

a. DIC

Question 10

10. Which condition is classified as immunologic thrombo-cytopenia?
    a. DIC
    b.ITP
    c.Storage pool defects
    d. Bernard-Soulier syndrome

Answer 10

b.ITP