14. Hypoproliferative Anemia: Anemia Associated with Systemic Diseases

Question 1

1. Which of the following lists of laboratory findings would be most characteristic of the anemia of chronic disease?
   a. Normocytic, hypochromic anemia; high serum iron level; increased TIBC; decreased ferritin levels.
   b.Normocytic, normochromic anemia; low serum iron level; decreased TIBC; increased ferritin levels.
   c.Microcytic,hypochromic anemia; normal serum iron level; decreased TIBC; normal ferritin levels.
   d. Macrocytic, normochromic anemia; low serum iron level; decreased TIBC; decreased ferriin levels.

Answer 1

b.Normocytic, normochromic anemia; low serum iron level; decreased TIBC; increased ferritin levels.

Question 2

2.Which of the following are causes for the anemia of chronic disease?
a.Shortened RBC lifespan
b. Impaired iron metabolism
c. Suppression of erythropoiesis by cytokines
d.All of the above

Answer 2

d.All of the above

Question 3

3.What are the main factors responsible for reducing ery-thropoiesis in anemia of chronic disease?
a. Cytokines from macrophages and lymphocytes
b. Antibodies from B lymphocytes
c. Erythropoietin from the kidney
d. Polyamines associated with renal failure

Answer 3

a. Cytokines from macrophages and lymphocytes

Question 4

4.What is the treatment for anemia of chronic disease?
a. Blood transfusion
b.Iron therapy
c. Treatment of the underlying inflammatory process
d.Human recombinant IL-1

Answer 4

c. Treatment of the underlying inflammatory process

Question 5

5.Which diseases do not cause anemia of chronic disease?
a.Malignancy and neoplastic processes
b.Connective tissue disorders
c.Bacterial and fungal infections
d.Endocrine, kidney,and liver disease

Answer 5

d.Endocrine, kidney,and liver disease

Question 6

6.What is the primary cause of anemia associated with renal disorders and renal failure?

a. Blood loss from dialysis
b. Decreased erythropoietin production
c. hemolytic processes
d. Vitamin B12 and folate deficiencies

Answer 6

b. Decreased erythropoietin production

Question 7

7. What is a typical appearance of anemia associated with liver disease?

a. Spherocytic red blood cell morphology
b.Hypochromic,microcytic red blood cell morphology
c.Macrocytic,normoblastic red blood cell morphology
d. Macrocytic,megaloblastic red blood cell morphology

Answer 7

c.Macrocytic,normoblastic red blood cell morphology

Question 8

8.Macrocytosis in liver disease is caused by all of the following except:

a.Abnormal lipid metabolism
b.Direct effects of alcohol
c.Iron deficiency
d. Vitamin B1: and folate deficiency

Answer 8

c.Iron deficiency

Question 9

9.What are the typical hematologic findings associated with anemin from endocrine dysfunction?

a. Mild nonnocye,pormochromic anemia
b. Anemie, abacnsait platelcis, and coagulopathy
c. Target cells, macrocytes, and acanthocytes
d. Marked anisocytosis and poikilocytosis, and dysfunctional leukocytes

Answer 9

a. Mild nonnocye,pormochromic anemia

Question 10

10.Leukoerythroblastosis with teardrop-shaped red blood cells is indicative of:
a.Bone marrow fibrosis
b.Bone marrow stress
c.Abnormal lipid metabolism
d.Renal disease

Answer 10

a.Bone marrow fibrosis

Question 11

11.The anemia of infancyis:
a.Physiologic
b.Well tolerated
c.Due to a switching from liver production of erythro-poietin to that of renal production
d. All of the above

Answer 11

d. All of the above

Question 12

12. The anemia of prematurity is:

a.A subset of the anemia of infancy
b. Often complicated by blood loss/frequent blood drawing
c. Well tolerated
d. A and B
e. All of the above

Answer 12

d. A and B

Question 13

13. Delta check of hemoglobin values for a patient helps with:

a.anemia of infancy
b.anemia of endocrine disorders
c. anemia due to improperly collected laboratory samples
d. anemia due to liver disease/alcoholism

Answer 13

c. anemia due to improperly collected laboratory samples