17. Chronic Myeloproliferative Disorders: I. Chronic Myclogenous Leukemia

Question 1

1. What is the M:E ratio in patients with CML (chronic myelogenous leukemia) ?

a.1:10
b.1:5
c.10:1
d.3:1

Answer 1

c.10:1

Question 2

2.What is the chromosomal abnormality in CML?
a.t(8;14)
b.t(9;22)
c.t(1;12)
d. Trisomy 12

Answer 2

b.t(9;22)

Question 3

3.Which of the following is not consistent with leukemoid reaction?
a. High WBC count
b. Associated with a bacterial infection
c.Presence of Philadelphia chromosome
d.High LAP

Answer 3

c.Presence of Philadelphia chromosome

Question 4

4. All of the following are characteristics of chronic leukemias except:
   a. Insidious onset
   b. Mature leukemia cells
   c.Found in adults
   d.Found in all ages

Answer 4

d.Found in all ages

Question 5

5.Which phase of CML carries the worst prognosis and is generally unresponsive to treatment?

a. Chronic
b. Accelerated
c. Blast
d. Refractory

Answer 5

c. Blast

Question 6

6. Environmental factors that are associated with an increased risk of developing leukemia include :

a. Ionizing radiation
b. Chemicals and drugs
c. Viruses
d. All of the above

Answer 6

d. All of the above

Question 7

7.Which of the following myeloproliferative disorders is characterized by a decreased LAP score?

a.CML
b.IMF
c. ET
d. PV

Answer 7

a.CML

Question 8

8. Most patients (85%) are diagnosed in which phase of CML?

a. Accelerated phase
b. Chronic phase
c. Blast phase
d. All of the above

Answer 8

b. Chronic phase

Question 9

9. The blast phase of CML is defined by what percent of blasts found in the peripheral blood or bone marrow?
   a.50%
   b.10%
   c.80%
   d.20%

Answer 9

d.20%

Question 10

10.Which of the following is characteristic of the acceler-ated phase of CML?

a. Persistent thrombocytosis or thrombocytopenia
b. Blasts greater than 5% in the peripheral blood or bone marrow
c.Basophilia greater than 20%
d.All of the above

Answer 10

d.All of the above