24. Introduction to Hemostasis

Question 1

1. Which of the following is true concerning the organelle zone?
   a.Responsible for metabolic activities of the platelet
   b.Contains dense granules,a granules,and glycocalyx
   c.Contains the dense tubular system which is the site of prostaglandin synthesis,calcium release, and platelet relaxation
   d. Contains the OCS to deliver stored products to the platelet surface

Answer 1

a.Responsible for metabolic activities of the platelet

Question 2

2.What events are involved in the normal formation of a platelet plug?
a.Adhesion,activation,fibrinolysis,secondary hemostasis
b.Aggregation,coagulation,release reaction,lupus anti-coagulant
c.Release action, adhesion,lupus anticoagulant,sec-ondary hemostasis
d. Activation, adhesion, aggregation, release reaction

Answer 2

d. Activation, adhesion, aggregation, release reaction

Question 3

3. What product is responsible for stabilization of the hemostatic plug?
   a.TXA2
   b.PF3
   c.Fibrin
   d.GPIIb

Answer 3

c.Fibrin

Question 4

4.Which of the following are classified as contact group proteins?
a. Factors II, VII, IX, X
b. Factors XII, XI, PK,HMWK
c. Factors I, V,VIII, XIII
d. Factors I,II,V,X

Answer 4

b. Factors XII, XI, PK,HMWK

Question 5

5.Which of the following are classified as prothrombin group proteins?
a. Factors II, VII,IX,X
b. Factors XII, XI,PK,HMWK
c.Factors I, V, VIII,XIII
d. Factors I,II, V,X

Answer 5

a. Factors II, VII,IX,X

Question 6

6.Which of the following are classified as fibrinogen group proteins?
a. Factors II, VII, IX, X
b. Factors XII, XI, PK, HMWK
c. Factors I, V,VIII,XIII
d.Factors I,II,V,X

Answer 6

c. Factors I, V,VIII,XIII

Question 7

7.Which of the following factors are dependent on vitamin K for synthesis?
a. Factors II, VII, IX, X
b. Factors XII, XI, PK, HMWK
c. Factors I, V,VIII,XIII
d.Factors I,II,V,X

Answer 7

a. Factors II, VII, IX, X

Question 8

8. Which of the following factors are unique to the extrin-sic system?
   a.Factors XII, XI, X,IV.VIII,V,II,I
   b.Factors III,VII
   c. Factors VII, X, V, II, I
   d. Factors XII, XI, IV, PF3, VIII

Answer 8

b.Factors III,VII

Question 9

9.What events take place in the extrinsic system ?

a. Activation of factor X to Va
b. Acceleration of intrinsic pathway by enhancement of the activity of factors XII to XI
c. Activation of factor XII to XIIa to initiate clotting
d. Activation of factor VII to VIIa in the presence of Ca2+ and factor III

Answer 9

d. Activation of factor VII to VIIa in the presence of Ca2+ and factor III

Question 10

10.Which of the followingfactors areunique to the intrinsic system?
a.Factors XII,XI,IX,VIII,X,V,II,I,Fletcher, Fitzgerald
b.Factors XII,XI,IX,VIII
c. Factors VII,X, V,II,I
d.Factors III,VII,X,V,II,I

Answer 10

b.Factors XII,XI,IX,VIII

Question 11

11.What factor is not found inthecommon pathway?
a.Factor X
b.Factor V
c.PF3
d.Factor XII

Answer 11

d.Factor XII

Question 12

12.Which of the following is a function of thrombin?
a.Conversion offibrinogen to fibrin
b.Activation of factor XIII to stabilize fibrinolysis
c. Conversion of factor VII to XIIa
d.Enhancement of factor V,VIII, and XI activity

Answer 12

a.Conversion offibrinogen to fibrin

Question 13

13. Which of the following is a function of plasmin?
    a.Cleavage of T-PA
    b.Destruction of fibrin
    c.Conversion of XII to XIa
    d. Inhibition of XIa

Answer 13

b.Destruction of fibrin

Question 14

14. What is the purpose of the PT test in monitoring hemostasis?
    a.Measures factors of the extrinsic pathway
    b.Detects platelet decrease or dysfunction
    c.Detects presence of aspirin
    d.Monitors heparin therapy

Answer 14

a.Measures factors of the extrinsic pathway

Question 15

15.What is the purpose of the APTT test in monitoring hemostasis?

a. Monitoring heparin anticoagulation
b. Detects deficiency of factors for both intrinsic and extrinsic pathways
c.Measures circulating FDPs
d.Detects platelet dysfunction

Answer 15

a. Monitoring heparin anticoagulation