33. Coagulation Procedures

Question 1

10.Using the test to measure D-dimer,which test results would be indicative of a patient having DIC?(Assume the fibrinogen concentration is indicative of DIC.)

a.D-dimer test result of 800 ng/mL of D-dimer units; increased PT and APTT; decreased platelet count

b.D-dimer test result of 800 ng/mL of D-dimer units:decreased PT and APTT; increased platelet count

c.D-dimer test result of 230 ng/mL;increased PT, decreased APTT;decreased platelet count

d. D-dimer test result of 230 ng/mL; decreased PT, increased APTT; increased platelet count

Answer 1

a.D-dimer test result of 800 ng/mL of D-dimer units; increased PT and APTT; decreased platelet count

Question 2

1. What is measured by a bleeding time?

a.Platelet number
b.Platelet function
c. Intrinsic and extrinsic coagulation systems
d.A and B

Answer 2

d.A and B

Question 3

2. Which platelet aggregation result would be characteristic for patients with Bernard-Soulier syndrome?

a. Incomplete aggregation with ADP
b.Primary wave of aggregation in response to collagen
c.Abnormal ristocetin-induced platelet aggregation
d.Primary wave of aggregation with epinephrine

Answer 3

c.Abnormal ristocetin-induced platelet aggregation

Question 4

3.Which of the following tests measures the intrinsic path-way of coagulation and is used to detect factor deficiencies and hypofibrinogenemia and to monitor heparin therapy?

a. Activated partial thromboplastin time
b. Prothrombin time
c.Quantitative factor assay
d. Stypven time test (Russell’s vper venom time test)

Answer 4

a. Activated partial thromboplastin time

Question 5

4.Which test measures the extrinsic pathway of coagula-tion and is used to measure factor deficiencies and moni-tor oral coagulation therapy?

a.Activated partial thromboplastin time
b.Prothrombin time
c.Quantitative factor assay
d.Stypven time test(Russell’s viper venom time test)

Answer 5

b.Prothrombin time

Question 6

5.Which test does not measure defects in intrinsic or rinogen and dysfibrinogenemia,as well as the presence of circulating anticoagulants?

a. Thrombin time
b.Prothrombin time
c. Reptilase time
d. Fibrinogen

Answer 6

a. Thrombin time

Question 7

6.Which of the following conditions would show a short clotting time, indicating high fibrinogen levels?
a.DIC
b.Liver disease
c.Pregnancy
d. Fibrinolysis

Answer 7

c.Pregnancy

Question 8

7.Which condition would most likely show a decrease in factor VIII activity?
a.Hemophilia B
b.Liver disease
c.Myeloproliferative syndrome
d.von Willebrand disease

Answer 8

d.von Willebrand disease

Question 9

8. Which APTT result would indicate the presence of a strong circulationg inhibitor ?

a. APTT not corrected by the addition of normal plasma
b. Normal APTT that prolongs upon incubation at 37C
c. APTT corrected by the addition of normal plasma
d. Any of the above results

Answer 9

a. APTT not corrected by the addition of normal plasma

Question 10

9.Which of the following are criteria for the laboratory detection of lupus anticoagulants ?

a.Abnormal APTT and/or PT
b. Correction of APTT after platelet neutralization procedure
c.Correction of APTT after mixing studies
d.A and B

Answer 10

d.A and B