6. Iron Metabolism and Hypochromic Anemias

Question 1

1.The average adult has a total body iron content of:
a.25mg
b.100mg
c.250mg
d.3500mg

Answer 1

d.3500mg

Question 2

2. Two-thirds of the total body iron is present as:
   a.Hemosiderin
   b.Ferritin
   c. Transferrin
   d.Hemoglobin iron

Answer 2

d.Hemoglobin iron

Question 3

3. One milligram of blood contains:
   a.2 mg of iron
   b.1 mg of ion
   c.0.5 mg of iron
   d.10 mg of iron

Answer 3

c.0.5 mg of iron

Question 4

4. On average, what percentage of the ingested iron is ab-sorbed each day?
   a.25 % to 35%
   b.5% to 10%
   c.80% to 90%
   d.100%

Answer 4

b.5% to 10%

Question 5

5. Dietary iron is absorbed predominantly in the:
   a.Stomach
   b. Duodenum and first part of the jejunum
   c.Transverse colon
   d.Sigmoid colon

Answer 5

b. Duodenum and first part of the jejunum

Question 6

6. The protein responsible for transporting iron in the bloodstrearn is:
   a. Hemoglobin
   b.Hemosiderin
   c. Transferrin
   d.Ferritin

Answer 6

c. Transferrin

Question 7

7.The hypochromic anemias represent a related group of disorders with:
a. A quantitative defect in hemoglobin synthesis
b. A qualitative defect in globin protein chains
c.Excess hemoglobin synthesis
d.Vitamin B12 and folate deficiency

Answer 7

a. A quantitative defect in hemoglobin synthesis

Question 8

8. The most common cause of hypochromic anemia is:
   a. Sideroblastic anemia
   b. Megaloblastic anemia
   c. Iron deficiency anemia
   d. Lead poisoning

Answer 8

c. Iron deficiency anemia

Question 9

9. In the older patients, iron deficiency most often develops from:
   a. Impaired absorption of iron
   b.Poor diet
   c.Chronic gastrointestinal bleeding
   d.The aging process

Answer 9

c.Chronic gastrointestinal bleeding

Question 10

10.Microcytosis of red blood cells is reflected by:
a.Increased MCV
b.Decreased MCV
c.Increased hemoglobin concentration
d.Decreased hemoglobin concentration

Answer 10

b.Decreased MCV

Question 11

11. Anemia of chronic disease is commonly associated with each of the following except:
    a.Infections
    b.Malignant neoplasms
    c. Autoimmune disorders
    d.A congenital defect

Answer 11

d.A congenital defect

Question 12

12.Each of the following are causes of secondary siderob-lastic anemias except:

a. Alcohol
b. Lead
c. Medications
d. Radiation therapy

Answer 12

d. Radiation therapy

Question 13

13. A common feature of sideroblastic anemia is which of the following?
    a.Ringed sideroblasts
    b.Decreased iron
    c.Decreased ferritin
    d. Macrocytes

Answer 13

a.Ringed sideroblasts

Question 14

14. Which of the following is the most sensitive assay in screening for hereditary hemochromatosis?
    a.Serum iron
    b.Serum ferritin
    c. Transferrin saturation
    d. Total iron-binding capacity

Answer 14

c. Transferrin saturation

Question 15

15. The most often cause of secondary hemochromatosis is:
    a.Drugs
    b. Diet
    c.Repeated blood transfusions
    d.Malabsorption

Answer 15

c.Repeated blood transfusions