19. Myelodysplastic Syndromes (MDS)

Question 1

1. Which type of anemia is most common in MDS?
   a.Microcytic,hypochromic
   b.Normocytic,hypochromic
   c.Macrocytic,normochromic
   d.Dimorphic

Answer 1

c.Macrocytic,normochromic

Question 2

2. Which of the following morphological abnormalities are helpful in the diagnosis of MDS?
   a. Pseudo-Pelger-Huët and hypogranulation
   b.Ringed sideroblasts
   c.Micromegakaryocytes,monolobular megakaryocytes
   d.All of the above

Answer 2

d.All of the above

Question 3

3.Which of the following criteria will differentiate RAEB-t from AML of the M2 type?
a. Thrombocytopenia
b. Anemia
c. The finding of t(8;21)
d. Blast less than 5%

Answer 3

c. The finding of t(8;21)

Question 4

4. Which of these cell surface antigens is of prognostic sig-nificance in MDS?
   a.CD19
   b.CD HLA-DR
   c.CD34
   d.CD33

Answer 4

c.CD34

Question 5

5. Which one of these MDS subgroups has the most favor-able prognosis?
   a. RAEB
   b.CMML
   c.RA
   d. RARS

Answer 5

d. RARS

Question 6

6.Which type of treatment may offer a cure in patients with MDS?
a.Chemoradiotherapy
b. Allogeneic bone marrow transplantation
c. Autologous bone marrow transplantation
d. Growth factors such as G-CSF

Answer 6

b. Allogeneic bone marrow transplantation

Question 7

7.Which of the following agents may lead to secondary MDS(sMDS)?

a. Hydrocortisone
b. Alkylating agents
c. Irradiated blood components
d. folic acid

Answer 7

b. Alkylating agents

Question 8

8.Which of the following is most likely to affect prognosis in MDS?

a.Leukopenia
b. Increased bone marrow myeloblasts
c. Erythroid hyperplasia
d. Thrombocytosis

Answer 8

b. Increased bone marrow myeloblasts

Question 9

9.In female patients with RA and elevated platelet counts,which chromosome abnormality is most often found?
a.5q-
b.t(8;21)
c.7q-
d. t(15;17)

Answer 9

a.5q-

Question 10

10.Which of the following biologic or genetic anomalies are important in the pathogenesis of MDS?
a.Chromosomal translocations
b.Chromosomal deletions
c. Hemolysis
d. Increased intramedullary apoptosis

Answer 10

b.Chromosomal deletions

Question 11

11.Which of the MDS subtypes is more closely related to the chronic myeloproliferative disorders?

a.RAEB
b.CMML with WBC>WBC>13×10^9/L
c.CMML with WBC<WBC<13×10^9/L
d. RARS

Answer 11

b.CMML with WBC>WBC>13×10^9/L

Question 12

12. Which MDS scoring system is most often used today?

a.FAB
b. IPSS
c.Sanz
d.Bournemouth

Answer 12

b. IPSS