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*** Hematology & Fundamentals of Hemostasis 5th > 21. The Lymphomas > Flashcards

21. The Lymphomas Flashcards

1
Q
  1. What infectious agent is most commonly associated with the pathogenesis of Hodgkin’s lymphoma ?
    a.Echovirus
    b.Herpesvirus
    c.Helicobacter pylori
    d.Epstein-Barr virus
A

d.Epstein-Barr virus

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2
Q

2.The cell characteristic of all types of classic Hodgkin’s lymphoma is the:
a.Lacunar cell
b.L&H cell
c.Reed-Sternberg cell
d.Sézary cell

A

c.Reed-Sternberg cell

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3
Q

3.An asymptomatic mediastinal mass affecting a young woman is a common form of presentation for which type of Hodgkin’s lymphoma?
a.Nodular sclerosing
b. Lymphocyte-predominant
c.Mixed cellularity
d.Lymphocyte depletion

A

a.Nodular sclerosing

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4
Q

4.All follicular center lymphomas are composed of a mixture of:
a.Small cleaved and small noncleaved cells
b.Centrocytes (small cleaved) and centroblasts (large noncleaved) cells
c.Large cleaved cells and immunoblasts
d.Prolymphocytes and paraimmunoblasts

A

b.Centrocytes (small cleaved) and centroblasts (large noncleaved) cells

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5
Q

5.Small lymphoeytie lymphoma is characterized by all of the following exceptt
a.Indolent but incurable
b. Usually CD19+,CD5+,CD23+,CD10-
c.Growth centers
d.t(14;18)

A

d.t(14;18)

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6
Q

6.Translocations involving the BCLI and IgH genes are commonly associated with which low-grade B-cell lymphoma?
a.Small lymphocytic
b.Lymphoplasmacytic
c.Mantle cell
d.Marginal zone

A

c.Mantle cell

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7
Q

7.Lymphomatous polyposis is a type of
a.Small lymphocytic lymphoma
b.Large-cell lymphoma
c.Mantle cell lymphoma
d.MALT lymphoma

A

c.Mantle cell lymphoma

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8
Q

8.MALT lymphomasare characterized by all of the following except:
a. Extranodal involvement
b. Associated follicular hyperplasia
CD19+,CD5+,CD10+p c.CD19+,CD5+,CD10+phenotype
d.t(11;18)

A

c.CD19+,CD5+,CD10+phenotype

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9
Q
  1. A lymphoma expressing a monoclonal B-cell phenotype with coexpression of CD10 and rearrangement of the BCL2 gene is most likely derived from:
    a.Follicular center cells
    b.Mantle cells
    c.Marginal zone cells
    d.Interfollicular cells
A

a.Follicular center cells

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10
Q
  1. Burkitt’s lymphoma is histologically characterized by which of the following?
    a.Uniform nuclei
    b.High mitoticrate
    c.“Starry sky”pattern
    d.All of the above
A

d.All of the above

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11
Q

11.Lymphoblastic lymphomas are associated with all the following except:
a. High frequency of developing acute lymphoblastic leukemia
b.Mediastinal mass
c.Lisually express B-cell phenotype
d. Potentially curable in young patients

A

c.Lisually express B-cell phenotype

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12
Q

12.All of the following are T-cell disorders except:
a.Mycosis fungoides
b. Sézary syndrome
c.Hepatosplenic gamma/delta lymphoma
d. Burkitt’s lymphoma

A

d. Burkitt’s lymphoma

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13
Q

13.A lymphoma associated with infection by a type C reter virus is:
a.Endemic to Japan
b.Associated with hypercalcemia
c.Usually rapidly fatal
d.All of the above

A

d.All of the above

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14
Q

14.The immunophenotypic definition of B-cell monoclonality i
a.Clonal rearrangement of the IgH gene
b.Loss of B-cell antigens by the malignant cells
c.Expression of a single light-chain class
d. Expression of a single heavy-chain class

A

c.Expression of a single light-chain class

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15
Q

15.Alternatives to karyotypic analysis for the demonstration of chromosomal translocations include:
a.Southern blot analysis
b.PCR
c.FISH
d.All of the above

A

d.All of the above

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16
Q
  1. Reed-Sternberg cells usually express the following immunophenotype:
    a.CD45+,CD30+,CD15+
    b.CD45-,CD30+,CD15+
    c.CD45+,CD30+,CD15-
    d.CD45-,CD30-,CD15+
A

b.CD45-,CD30+,CD15+

17
Q

17.All of the following are true regarding the low-grade non-Hodgkin’s lymphomas except:
a. Survival without treatment averages more than 5 years
b.Disease is usually advanced at diagnosis
c. Multiagent chemotherapy can prolong survival
d.Cure is possible in more than 50% of cases

A

d.Cure is possible in more than 50% of cases

18
Q
  1. The diffuse aggressive lymphomas are:
    a.Seldom curable
    b.Rapidly fatal if untreated
    c. Best treated with a combination of surgery and radiotherapy
    d. Single-agent chemotherapy is the treatment of choice
A

b.Rapidly fatal if untreated

19
Q

19.The staging system for Hodgkin’s lymphoma and the non-Hodgkin’s lymphomas is:

a.Working Formulation
b.Duke’s staging system
c.Rye staging system
d.Ann Arbor staging system

A

d.Ann Arbor staging system

20
Q
  1. A patient with Hodgkin’s lymphoma that is localized to lymph nodes above and below the diaphragm and is asso-ciated with drenching night sweats would be classified as:
    a.Stage IIIE
    b.Stage IIB
    c.Stage IIIB
    d.Stage IIIA
A

c.Stage IIIB

*** Hematology & Fundamentals of Hemostasis 5th (36 decks)

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