6. Complex Molecules Flashcards
arachidonic acid is
___ carbon FA
20
arachidonic acid is cleaved from cell membrane by enzyme
phospholipase A2
prostaglandins and thromboxanes are products of the enzyme
cyclooxygenase
leukotrienes are products of the enzymes
lipoxygenase
EICOSANOIDS
prostaglandins
Thromboxane
Prostacyclin
Leukotrienes
mediators of infammation, pain and protect gastric mucosa
Prostaglandin
promotes thrombosis (platelet adhesion and aggegation) and vasoconstriction produced by platelets
thromboxane
inhibits thrombosis stimulates vasodilation produces endothelial cells
prostacyclin
keeps ductus arteriosus open, used for erectile dysfunction
PGE1, alprostadil
results in vasodilation and relaxation of smooht muscle used to induce abor
PGE2
results in vasoconstriction and contraction of smooth muscle, stiulates uterine contractions
PGF2 α
slow-reacting substances of anaphylaxis, potent bronchial constriction
(role in pathology of asthma )
leukotrienes C4,D4, E4
long chain FA attached to sphingosine backbone
ceramide
glycolipids are derivatives of
ceramide
glycolipid with
X: Hydrogen atom
ceramide
glycolipid with
X: glucose or galactose
cerebroside
glycolipid with
X:di- or tri- or tetra saccharide
globoside
glycolipid with
X:N-acetylneuraminic acid
ganglioside
glycolipid with
X: sulfated glucose
sulfatide
- cell adhesion, recognition, growth , development
* important in neural tissue
glycolipids
phospholipid with sphingosine backbone
sphingophospholipids