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Basic Biochemistry > 3. Glycoproteins, GAG, Sphingolipids, ABO System > Flashcards

3. Glycoproteins, GAG, Sphingolipids, ABO System Flashcards

1
Q

ABO system is discovered by

A

Landsteiner

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2
Q

on membranes of RBC, the oligosaccharides that determine the specific natures of ABO susbatnces appear to be mostly present in ___

A

glycosphingolipids

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3
Q

Type A

A

N-acetylgalactosamine

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4
Q

Type B

A

galactose

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5
Q

Type B

A

Galactose

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6
Q

Type AB

A

N-acetylgalactosamine

Galactose

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7
Q

Type O

A

neither

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8
Q

demyelinating disease in which there is loss of both phospholipids and sphingolipids from white matter with resulting dec. CSF phospholipids

A

Multiple sclerosis

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9
Q

Glycosaminoglycans

A
  1. hyaluronic acid
  2. chondroitin sulfate
  3. keratan sulfate
  4. hepatin
  5. heparan sulfate
  6. dermatan sulfate
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10
Q

sugar units of

hyaluronic acid

A

N-acetylglucosamine

glucuronic acid

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11
Q

sugar units of

chondroitin sulfate

A

N-acetylglucosamine

glucuronic acid

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12
Q

sugar units of

keratan sulfate

A

N-acetylglucosamine

galactose

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13
Q

sugar units of

heparin

A

glucosamine

iduronic acid

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14
Q

sugar units of

heparan sulfate

A

Glucosamine

Glucuronic acid

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15
Q

sugar units of

dermatan sulfate

A

N-acetylgalactosamine

iduronic acid

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16
Q

which GAG
is located in

skin, synovial fluid,
bone, cartilage,
vitreous humor
embryonic tissues

A

hyaluronic acid

17
Q

which GAG
is located in

cartilage , bone, CNS

A

chondroitin sulfate

18
Q

which GAG
is located in

cornea, cartilage
loose connective tissue

A

keratan sulfate

19
Q

which GAG
is located in

mast cells, liver, lung, skin

A

heparin

20
Q

which GAG
is located in

skin , kidney,
basement membrane

A

heparan sulfate

21
Q

which GAG
is located in

skin, wide distribution

A

dermatan sulfate

22
Q

Mannose residue of oligosaccharide is NOT PHOSPHORYLATED hence, the glycoprotein does not reach the lysosome where it is supposed to be degraded

large inclusion bodies in cells

A

I-cell disease

23
Q

skeletal abnormalities
restricted joint movement
coarse facial features
severe psychomotor impairment

A

I-cell disease

24
Q

fertilization is interacion of which proteins

A

zona pellucida : ZP3 (O linked glycoprotein)

sperm: galactosyl transferase

25
Q

which protein allows leukocytes to adhere endothelium

A

selectins

26
Q

glycoprotein that allows new proteins to exit infected cells

A

neuraminidase

27
Q

HIV surface glycoprotein used to attach to cells

A

gp120

28
Q

HIV surface glycoprotein used to used to FUSE TO HOST CELL MEMBRANE

A

gp41

Basic Biochemistry (50 decks)

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