3. Glycoproteins, GAG, Sphingolipids, ABO System Flashcards
ABO system is discovered by
Landsteiner
on membranes of RBC, the oligosaccharides that determine the specific natures of ABO susbatnces appear to be mostly present in ___
glycosphingolipids
Type A
N-acetylgalactosamine
Type B
galactose
Type B
Galactose
Type AB
N-acetylgalactosamine
Galactose
Type O
neither
demyelinating disease in which there is loss of both phospholipids and sphingolipids from white matter with resulting dec. CSF phospholipids
Multiple sclerosis
Glycosaminoglycans
- hyaluronic acid
- chondroitin sulfate
- keratan sulfate
- hepatin
- heparan sulfate
- dermatan sulfate
sugar units of
hyaluronic acid
N-acetylglucosamine
glucuronic acid
sugar units of
chondroitin sulfate
N-acetylglucosamine
glucuronic acid
sugar units of
keratan sulfate
N-acetylglucosamine
galactose
sugar units of
heparin
glucosamine
iduronic acid
sugar units of
heparan sulfate
Glucosamine
Glucuronic acid
sugar units of
dermatan sulfate
N-acetylgalactosamine
iduronic acid
which GAG
is located in
skin, synovial fluid,
bone, cartilage,
vitreous humor
embryonic tissues
hyaluronic acid
which GAG
is located in
cartilage , bone, CNS
chondroitin sulfate
which GAG
is located in
cornea, cartilage
loose connective tissue
keratan sulfate
which GAG
is located in
mast cells, liver, lung, skin
heparin
which GAG
is located in
skin , kidney,
basement membrane
heparan sulfate
which GAG
is located in
skin, wide distribution
dermatan sulfate
Mannose residue of oligosaccharide is NOT PHOSPHORYLATED hence, the glycoprotein does not reach the lysosome where it is supposed to be degraded
large inclusion bodies in cells
I-cell disease
skeletal abnormalities
restricted joint movement
coarse facial features
severe psychomotor impairment
I-cell disease
fertilization is interacion of which proteins
zona pellucida : ZP3 (O linked glycoprotein)
sperm: galactosyl transferase
which protein allows leukocytes to adhere endothelium
selectins
glycoprotein that allows new proteins to exit infected cells
neuraminidase
HIV surface glycoprotein used to attach to cells
gp120
HIV surface glycoprotein used to used to FUSE TO HOST CELL MEMBRANE
gp41
