22. Vitamins Flashcards
group of organic nutrients required for diff biochemical fx
vitamins
forms of Vit A
- retinol
- retinal
- retinoic acid
- ß-carotene
source of ß-carotene
carrots
sweet potatoes
sources of vit A
liver
eggs
whole milk
butter
carrots
sweet potatoes
this is a vitamin that fx
as component of visual pigment rhodopsin
Vit A (11-cis retinal)
this is a vitamin that
maintains fluidity of cell memranes
vit E
this is a vitamin that fx
lipid soluble antioxidant
beta carotene
vit E
this is a vitamin that
support gametogenesis
retino and retinal
maintain calcium balance
vit D
this is a vitamin that fx
as coenzyme for y-carboxylation of glutamate residue in clotting factors and other proteins
factors II, VII, IX, X
proteins C and S
vitamin K
this is a vitamin that fx as coenzyme for •pyruvate dehydrogenase •alpha keto glutarate dehydrogenase •branched chain amino acid dehydrogenase •transketolases
thiamine
Vit B1
this is a vitamin that fx
as electron carries in redox rxns
vit B2 riboflavin
vit B3 niacin
source ADP-ribose for nucleoproteins involved in DNA repair
vit B3 niacin
this vitamin inhibits lipolysis in adipose tissue
used to tx hyperlipidemia
vit B3 niacin
part of coenzyme A and acyl carrier protein for fatty acid synthesis and metabolism
vit B5
pantothenic acid
coenzyme for transamination of amino acids decarbozylation of glutamate and histidine ALA synthase Cystathionine synthase glycogen phosphorylase
pyridoxine
synthesis of niacin from tryptophan
requires this coenzyme
pyridoxine vit b6
active form of folic acid
tetrahydrofolate
receives 1 carbon fragments from donors (serine, glycine, histidine)
and transfers them to intermediates in synthesis of aa, purines, and thymine
folicacid vit b9
coenzyme for methionine synthase,
methylmalonyl coa mutase
vit b12 cobalamin
coenzyme for copper abd iron containing hydroxylases
- proline and lysine hydroxylases in collagen
- dopamine beta hydroxylase
ascorbic acid
this vitamin enhances absorption of inorganic iron
vit c
coenzyme for
pyruvate carboxylase
acetyl coa carboxylase
propionyl coa carboxylase
biotin
Vit H
test for vit B1 deficiency
erythrocyte transketolase activity assay
test for vit B6 deficiency
erythrocyte transaminase assay
test for vit B12 deficiency
schilling test
methylmalonic acid test
test for folate deficiency
miminoglutamic acid excretion test
lipid soluble vitamins composed of _______ units
isoprene units
vitamin D3
cholecalciferol
vit D2
ergocalciferol
this is normlly formed in the skin form 7-dehydrocholesterol when exposed to sunlight
vit D3
this is commonly added to milk and butter
vit D2
active form of vit D , which is a product of hydroxylation rxns in the liver and kidney
calcitriol
1,25- dihydroxyvitamin D
forms of BVit E
tocopherols
tocotrienols
sources of vit E
vegetable oils
liver
eggs
source of Vit D3
fatty fish
liver
egg yolk
antioxidant of cell membranes
Vit E
vit K from green vegetables
phylloquinone
vit K synthesized by intestinal bacteria
menaquinone
synthetic vit K
menadione
water soluble vitamins fx mainly as
enzyme cofactors
sources of thiamine
pork fish seafood beef yoghurt fortified rice cereals bread flour
forms of vit K
phylloquinone
menaquinone
menadione
active forms of riboflavin
FMN -flavine mononucleotide
FAD -flavine adenine dinucleotide
active forms of niacin
NAD+
Nicotinamide adenine dinucleotide
NADP+
Nicotinamide adenine dinucleotide phosphate
synthesize from tryptophan, in a process that requires pyridoxine
niacin
sources of niacin
tryptophan unrefned and enriched grains and cereal milk lean meat liver
sources of pantothenic acid
eggs
liver
yeast
active form of pyridoxine
pyridoxal 5’ phosphate
source of pyridoxine
potatoes and starchy vegetbles, non-citrus fruits -> pyridoxine
meat -> pyridoxal and pyridoxamine
active form of folic acid
tetrahydrofolate
sources of folic acid
fresh green vegetables
liver
active form of cobalamin
methylcobalamin
deoxyadenosylcobalamin
absorption of cobalamin requires
binding to cobalophilin and intrinsic factor
sources of vit b12
liver whole milk eggs oysters shrimp pork chicken
sore spongy gums
loose teeth
poor wound healing
bone fracture
scurvy - vit C deficiency
absorption of biotic inhibited by
avidin in egg whites