39. Pentose Phosphate Pathway Flashcards
pentose phosphate pathway also known as
texose monophosphate shunt
what is pentose phosphate pathway used for
- produces NADPH
- produces ribose -5- phosphate-> nucleotides
- provides mechanism for use of 5-carbon sugars
what is the substrate of pentose phosphate pathway
glucose -6- phosphate
where does pentose phosphate pathway happen
- RBC
- liver
- adipose
- adrenals
- thyroid
- testes
- lactating mammaries
•cytosol
important products of pentose phosphate pathway
NADPH
ribose-5-phosphate
rate limiting step of pentose phosphate pathway
Glucose-6-phosphate -> 6-phosphogluconate
oxidative, irreversible phase of PPP
first phase
non-oxidative , reversible phase of PPP
second phase
key enzymes of PPP
first phase: glucose-6- phosphate dehydrogenas
second: transketolases
cofactor: thiamine
product of first phase of PPP
2 NADPH
ribulose-5-phosphate
product of second phase of PPP
ribose-5-phosphate
fructose-6-phosphate
glyceraldehyde-3-phosphate
other carbs
- used for reductive biosynthesis of FA and steroids
- gluthathione reduction inside TBCs
- synthesis of Nitric oxidfe
- oxyge dependent bactericidal mechanisms of WBCs
NADPH
gluthathione (G-SH) removes H2O2 in a reaction catalyzed by
gluthathione peroxidase
reduced gluthathione is generated by
gluthathione reductase
requires NADPH
most common disease producing enzyme abnormality in humans
glucose-6- phosphate dehydrogenase deficiency