4/10

Question 1

competency

Answer 1

determined by a court, not a doctor

Question 2

drug induced lupus vs non drug induced lupus antibodies

Answer 2

drug = H1 histone linker antibodies
non = Smith

Question 3

MOA of ribavarin

Answer 3

same as mycophenolate, conversion of IMP to GMP

Question 4

urine dicarboxylic acids

Answer 4

present in MCAD deficiency due to omega decarboxylation because can’t break down fatty acids

Question 5

presentation of methylmalonyl CoA mutase deficiency

Answer 5

• early in life
• severe acidosis
• hyperammonia
• high MMA in urine

Question 6

garlic odor on breath

Answer 6

arsenic poisoning

Question 7

mechanism of arsenic poisoning

Answer 7

• binds lipoic acid

Question 8

TCA enzymes requiring CO2

Answer 8

isocitrate dehydrogenase and alphaketoglutarate dehydrogenase

Question 9

uncoupling agents

Answer 9

dinitrophenol and aspirin and brown fat

Question 10

Pompe’s trashes the….

Answer 10

pump (cardiomegaly)

Question 11

how fats and amino acids get into TCA cycle

Answer 11

succinyl CoA (can’t use acetyl CoA)

Question 12

sodium dependent glucose pumps are in…

Answer 12

instestines

Question 13

mcardles vs carnitine deficiency

Answer 13

mcardle’s = glycogen, carnitine = lipids

Question 14

egg whites prevent…

Answer 14

biotin absorption

Question 15

sources for gluconeogenesis

Answer 15

• alanine
• lactate
• odd chain fatty acids
• glycerol

Question 16

mechanism of gout in alcoholics

Answer 16

increase in NADH/NAD ratio leads to increase in lactic acid which competes with gout for trasnport leading to less excretion

Question 17

first step after glycolysis that occurs in mitochondria

Answer 17

pyruvate dehydrogenase

Question 18

isolated hyperammonemia

Answer 18

urea cycle disorder

Question 19

substitution in sickle cell

Answer 19

valine for glutamic acid

Question 20

vitamin that requires a kinase

Answer 20

B6

Question 21

B vitamin that can cause toxicity

Answer 21

B6 - peripheral neuropathy

Question 22

product of HMG CoA reductase

Answer 22

mevalonic acid

Question 23

rule of the pupil

Answer 23

in compression due to aneurysms, parasympathetic fibers are compressed and pupil is affected
- in diabetes, motor portion is most affected, pupil is spared

Question 24

pulsus paradoxus in lung disease

Answer 24

asthma and COPD

Question 25

Kussmal vs pulsus paradoxus

Answer 25

Kussmal in constrictive or restrictive

pulsus in tamponade

Question 26

reye syndrome

Answer 26

due to mitochondrial problem

Question 27

vasculitis with immune complexes

Answer 27

polyarteritis nodosa

Question 28

metanephric blastema cancer

Answer 28

Wilms tumor

Question 29

urachal remnants can lead to

Answer 29

adenocarcinoma of bladder