3/30 Flashcards

1
Q

blood pressure med causing peripheral edema

A

CCB (only one that is not a diuretic)

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2
Q

IbK kinase

A

activated during TLR binding, leading to ubiquitination of IkB, release of NFkB, leading to activation of immune cell

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3
Q

prolactin is activated by…

A

TRH and VIP (can occur in autoimmune thyroiditis

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4
Q

levels increased in menopause

A

FSH

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5
Q

more severe illness in Dengue is related to…

A

infection with different serotype

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6
Q

most important part of diptheria treatment

A

antitoxin (then antibiotics and vaccine)

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7
Q

mutations in hypertrophic cardiomyopathy

A

sarcomere proteins (beta-myosin heavy chain and myosin binding protein G)

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8
Q

mutation in muscular dystrophy

A

dystrophin

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9
Q

doxorubicin causes

A

dilated cardiomyopathy

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10
Q

submucosal gland in GI tract

A

in esophagus and duodenum

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11
Q

differential in dexamethasone suppression

A

ACTH can’t be suppressed = ectopic source

- can be suppressed = pituitary adenoma

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12
Q

age related eye changes

A

myopia can be improved because of worsening presbyopia (patient can think diet led to an improvement)

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13
Q

part of the heart most anterior

A

right ventricle (left sternal border in fourth intercostal space)

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14
Q

stages of lobar pneumonia

A
  1. congestion
  2. red hepatization
  3. gray hepatization
  4. resolution
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15
Q

antibiotic with increase in CK and myopathy

A

daptomycin

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16
Q

MOA of daptomycin

A

similar to vanco, creates membrane channels in cell wall

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17
Q

vitamin deficiency similar to B12

A

vitamin E (also folate)

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18
Q

type of gene VHL

A

ubiquitin ligase

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19
Q

type of gene BRCA

A

DNA repair

20
Q

blood pressure med causing pulmonary edema

A

mannitol (used with caution in patients with heart failure and pulmonary edema)

21
Q

somatic symptom disorder

A

anxiety or preoccupation with one symptom

22
Q

red pulp in spleen

A

removal of defective RBCs

23
Q

cord factor

A

in TB, leads to high virulence and serpentine growth

24
Q

hydroxylation of vitamin D

A

25 in the liver, 1 in the kidney

25
treatment of ophthalmopathy in graves
corticosteroids
26
systemic infection with cryptococcus =
meningoencephalitis
27
late complication of Fabry's
renal disease
28
warfarin induced skin necrosis
due to protein C or S deficiency (leads to prothrombotic state)
29
most specific for RA
anti-CCP
30
CFTR transporter in CF lungs
secretes Cl-, inhibiting sodium reabsorption by ENaC and keeping water in the lumen - in CF, Cl- cant be secreted, so more sodium is reabsorbed and more water comes in leading to dehydrated mucus
31
nerve that can be stimulated in obstructive sleep apnea
glossopharyngeal nerve
32
antibodies in CREST
anti centromere
33
pathway affected in fatty alcoholic steatosis
fatty acid oxidation leads to a build up of fat in liver
34
thing associated with poorly differentiated, aggressive breast tumors
increased expression of HER2/Neu (tyrosine kinase)
35
treatment for TCA overdose
sodium bicarb
36
mechanism for sequelae of endocarditis
septic embolization
37
fluctuating lymphadenopathy
follicular lymphoma
38
DRESS lab increase
eosinophils and ALT
39
causes of DRESS
anticonvulsants, allopurinol, sulfonamides, and antibiotics
40
neurotransmitter decreased in Huntingtons
GABA
41
endo vs exo nuclease
``` endo = in middle of molecule exo = front end of molecule ```
42
measles can make what vitamin deficiency worse
vitamin A
43
S3 is best heard....
at the end of expiration (heart is closest to chest wall)
44
SA node is located
in the right atrium near the opening of the SVC
45
encephalitis associated with flaccid paralysis
west nile
46
CD31
PECAM, seen in angiosarcoma of liver