3/18 Flashcards
1
Q
biochemistry in Huntingtons
A
gain of function mutation in CAG repeats that leads to deacetylation of histones
2
Q
defective neurotransmitter in Alzeimers
A
acetylcholine in nucleus basalis
3
Q
lab values in hypoaldosteronism
A
- high sodium
- low potassium
- low bicarb (H+ is no longer secreted - metabolic acidosis)
- high chloride to balance lost bicarb
4
Q
triad in VIPoma
A
- watery diarrhea (increase in cAMP)
- hypokalemia (secretion of K)
- achlorhydria (inhibits gastric acid secretion)
5
Q
paraneoplastic syndrome in squamous cell carcinoma
A
PTHrP
6
Q
ambiguous genitalia with maternal virilization
A
aromatase deficiency (to many androgens make it to mom)
7
Q
reactions that require B6
A
transaminase (remember that thiamine is for transketolase)
8
Q
hepatitis B replication
A
- semi double stranded DNA to RNA - reverse transcription back to DNA
9
Q
NK cells are activated by…..
A
gamma interferon and IL12
10
Q
fibroblast migration and proliferation are controlled by….
A
PDGF and TGF-beta
11
Q
poorly vascularized peripheral compartment
A
skeletal muscle, bone and fat
- for lipophilic drugs
