17: Lymphoma 1 Flashcards
What are four examples of lymphoproliferative diseases?
Lymphoma/lymphosarcoma, lymphoid leukaemia, plasma cell/mulitple myeloma, plasmacytoma (skin tumour)
What % of malignancies in cats are lymphomas?
30%
Which virus is lymphoma associated with in cats?
FeLV
What % of malignancies in dogs are lymphomas?
8-10%
Where in the genome is FeLV inserted?
Upstream of myc
What is the bovine version of FeLV?
Enzootic bovine leukaemia
What grade are lymphomas usually?
High
What % of lymphomas are B cell?
65-80%
What is the B cell marker?
CD79a
What is the T cell marker?
CD3
Is T cell or B cell a worse prognosis?
T cell
How many subtypes of malignant lymphoma are there?
More than 20
What is the best way to diagnose lymphoma?
Histopathology of a whole node following lymphadenectomy
What kind of lymphoma is the most common in the dog?
Multicentric
In what kind of dog is multicentric lymphoma most common?
Bull-type
What type of lymphoma is least common in the cat?
Multicentric
What is a complication of multicentric lymphoma?
Progresses to other organs
What stage are most lymphomas?
3 or 4
What is substage a?
Clinically well
What is substage b?
Clinical signs
What is stage 1 lymphoma?
Single node/organ
What is stage 2 lymphoma?
Single region +/- tonsil
What is stage 3 lymphoma?
Generalised lymph node
What is stage 4 lymphoma?
Hepatic and or splenic
What is stage 5 lymphoma?
Blood or other organ
What kind of lymphoma especially results in hyperCa?
T cell thymic
What are 4 other common complications of lymphoma?
Anaemia, thrombocytopaenia, WBC abnormalities, hypergammaglobulinaemia
What other organs can be affected by lymphoma in cattle?
Heart, abomasum, kidneys, ureters, epidural fat, intestine
What are two clinical signs of thymic lymphomas?
Facial swelling and resp distress
What age do thymic lymphomas present in dogs?
Variable
What kind of lymphomas are thymic usually?
T cell
What % of thymic lymphomas are FeLV positive?
90%
What is the most common lymphoma in adolescent cattle?
Thymic
Why won’t endoscopic grab biopsy not work for alimentary lymphoma?
Need deeper as can be diffuse or focal
What are clinical signs of alimentary lymphoma?
Weight loss and diarrhoea
What condition can resemble alimentary lymphoma?
IBD
What can be a complication of alimentary lymphoma if it is upper SI?
Obstruction
What can be a sign of alimentary lymphoma if it is lower LI?
Tenesmus/dyschezia
Which species/age most commonly get alimentary lymphoma?
Elderly cats
In which species is alimentary lymphoma less common?
Cattle
What is the second most common lymphoma in the horse?
Alimentary
Which breeds most commonly get T cell?
Boxer, bullmastiff etc
Which breeds most commonly get B cell?
Golden retriever
What’s an example of a low grade cutaneous lymphoma?
Epitheliotropic (round cells up to epithelium causing sloughing)
What’s an example of a high grade cutaneous lymphoma?
Primary cutaneous (more nodular and deep)
Which species gets extra-nodal lymphoma?
Cats
What are some extra-nodal sites?
Renal, spinal, ocular etc
Are extra nodal lymphomas bilateral or symmetrical?
Bilateral but not symmetrical
What are the symptoms of a spinal lymphoma?
Acute-onset paresis
How many lymph nodes should you FNA?
Several
Why should you not FNA submandibular lymph nodes?
Often reactive to dental disease
Which species is hard to diagnose lymphoma using FNA?
Cat
What four parameters do you need for staging?
Physical exam esp palpation, urinalysis, biochem (Ca, urea, liver), CBC (RBC, WBC, platelets)
