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17: Lymphoma 1 Flashcards

1
Q

What are four examples of lymphoproliferative diseases?

A

Lymphoma/lymphosarcoma, lymphoid leukaemia, plasma cell/mulitple myeloma, plasmacytoma (skin tumour)

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2
Q

What % of malignancies in cats are lymphomas?

A

30%

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3
Q

Which virus is lymphoma associated with in cats?

A

FeLV

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4
Q

What % of malignancies in dogs are lymphomas?

A

8-10%

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5
Q

Where in the genome is FeLV inserted?

A

Upstream of myc

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6
Q

What is the bovine version of FeLV?

A

Enzootic bovine leukaemia

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7
Q

What grade are lymphomas usually?

A

High

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8
Q

What % of lymphomas are B cell?

A

65-80%

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9
Q

What is the B cell marker?

A

CD79a

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10
Q

What is the T cell marker?

A

CD3

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11
Q

Is T cell or B cell a worse prognosis?

A

T cell

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12
Q

How many subtypes of malignant lymphoma are there?

A

More than 20

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13
Q

What is the best way to diagnose lymphoma?

A

Histopathology of a whole node following lymphadenectomy

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14
Q

What kind of lymphoma is the most common in the dog?

A

Multicentric

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15
Q

In what kind of dog is multicentric lymphoma most common?

A

Bull-type

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16
Q

What type of lymphoma is least common in the cat?

A

Multicentric

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17
Q

What is a complication of multicentric lymphoma?

A

Progresses to other organs

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18
Q

What stage are most lymphomas?

A

3 or 4

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19
Q

What is substage a?

A

Clinically well

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20
Q

What is substage b?

A

Clinical signs

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21
Q

What is stage 1 lymphoma?

A

Single node/organ

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22
Q

What is stage 2 lymphoma?

A

Single region +/- tonsil

23
Q

What is stage 3 lymphoma?

A

Generalised lymph node

24
Q

What is stage 4 lymphoma?

A

Hepatic and or splenic

25
What is stage 5 lymphoma?
Blood or other organ
26
What kind of lymphoma especially results in hyperCa?
T cell thymic
27
What are 4 other common complications of lymphoma?
Anaemia, thrombocytopaenia, WBC abnormalities, hypergammaglobulinaemia
28
What other organs can be affected by lymphoma in cattle?
Heart, abomasum, kidneys, ureters, epidural fat, intestine
29
What are two clinical signs of thymic lymphomas?
Facial swelling and resp distress
30
What age do thymic lymphomas present in dogs?
Variable
31
What kind of lymphomas are thymic usually?
T cell
32
What % of thymic lymphomas are FeLV positive?
90%
33
What is the most common lymphoma in adolescent cattle?
Thymic
34
Why won't endoscopic grab biopsy not work for alimentary lymphoma?
Need deeper as can be diffuse or focal
35
What are clinical signs of alimentary lymphoma?
Weight loss and diarrhoea
36
What condition can resemble alimentary lymphoma?
IBD
37
What can be a complication of alimentary lymphoma if it is upper SI?
Obstruction
38
What can be a sign of alimentary lymphoma if it is lower LI?
Tenesmus/dyschezia
39
Which species/age most commonly get alimentary lymphoma?
Elderly cats
40
In which species is alimentary lymphoma less common?
Cattle
41
What is the second most common lymphoma in the horse?
Alimentary
42
Which breeds most commonly get T cell?
Boxer, bullmastiff etc
43
Which breeds most commonly get B cell?
Golden retriever
44
What's an example of a low grade cutaneous lymphoma?
Epitheliotropic (round cells up to epithelium causing sloughing)
45
What's an example of a high grade cutaneous lymphoma?
Primary cutaneous (more nodular and deep)
46
Which species gets extra-nodal lymphoma?
Cats
47
What are some extra-nodal sites?
Renal, spinal, ocular etc
48
Are extra nodal lymphomas bilateral or symmetrical?
Bilateral but not symmetrical
49
What are the symptoms of a spinal lymphoma?
Acute-onset paresis
50
How many lymph nodes should you FNA?
Several
51
Why should you not FNA submandibular lymph nodes?
Often reactive to dental disease
52
Which species is hard to diagnose lymphoma using FNA?
Cat
53
What four parameters do you need for staging?
Physical exam esp palpation, urinalysis, biochem (Ca, urea, liver), CBC (RBC, WBC, platelets)

Clinical Pathology (30 decks)

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