10 Antiepileptic Drugs Flashcards
1
Q
Phenytoin (DPH)
A
Na channel blocker
副作用：喝醉酒一樣的感覺、眼球震顫、複視、多毛症、牙齦增生、致畸胎性
2
Q
Carbamazepine
A
Na channel blocker
可能引起 SJS/TEN、aplastic anemia、致畸胎性
3
Q
Lamotrigine (LTG)
A
Na channel blocker-II
4
Q
Topiramate
A
Na channel blocker-II
5
Q
Phenobarbital (PB)
A
Allosteric GABA agonist
6
Q
Clonazepam (CNZ)
A
Allosteric GABA agonist
7
Q
Vigabatrin (VGB)
A
抑制 GABA aminotransferase
8
Q
Gabapentin
A
抑制 Ca2+ channel α2δ subunit
9
Q
Pregabalin
A
抑制 Ca2+ channel α2δ subunit
10
Q
Ethosuximide (ESX)
A
抑制鈣離子通道
治療 Absence seizure
11
Q
Perampanel
A
AMPA 受體抑制劑
12
Q
Levetiracetam
A
Synaptic vesicle synthesis inhibition
13
Q
Valproate (VA)
A
Na channel blocker
Ca channel blocker
Increase GABA: 抑制 GABA-T and SSADH
副作用：嗜睡、干擾 NH3 代謝、tremor、孕毒性（spina bifida）
14
Q
Lorazepam
A
促進 GABAergic inhibition
即興發作時藥物
15
Q
Diazepam
A
促進 GABAergic inhibition
即興發作時藥物
