01 Sex Hormone

Question 1

Finasteride

Answer 1

5α reductase inhibitor, 治療 BPH and 雄性禿

Question 2

Anastrozole

Answer 2

Aromatase inhibitor, 治療乳癌

Question 3

Letrozole

Answer 3

Aromatase inhibitor, 治療乳癌

Question 4

Exemestane

Answer 4

Aromatase inhibitor, 治療乳癌

Question 5

Formestane

Answer 5

Aromatase inhibitor, 治療乳癌

Question 6

Tamoxifen

Answer 6

SERMs, Breast antagonist, endometrium and bone agonist, 治療乳癌

Question 7

Raloxifen

Answer 7

SERMs, breast and endometirum antagonist, bone agonist, 停經婦女預防骨質疏鬆

Question 8

Clomiphene

Answer 8

SERMs, 下視丘與腦垂腺前葉上的 ER antagonist，抑制 Estradiol 負回饋，導致 FSH, LH 分泌上升，促進排卵。

Question 9

Fulvestrant

Answer 9

Pure ER antagonist, 治療轉移性乳癌

Question 10

Mifepristone

Answer 10

PR antagonist, 使子宮內膜無法穩定、破壞絨毛使黃體退化，用於墮胎藥。

與 Misoprostol（PGE1 analog）併用，可刺激子宮收縮有助胚胎排出。

Question 11

Danazol

Answer 11

抑制 FSH, LH 脈動性釋放，使 Estradiol 減少。治療子宮內膜異位。

Question 12

Flutamide

Answer 12

AR antagonist, 治療 BPH 與轉移的前列腺癌、女性多毛症

Question 13

Spironolactone

Answer 13

AR antagonist, 治療女性多毛症

Aldosterone receptor antagonist, 利尿劑

Question 14

Cimetidine

Answer 14

主要是 H2 blocker，以前治療十二指腸潰瘍，但因為有 AR antagonist activity, 所以會有精子品質下降的副作用。

Question 15

Leuprolide

Answer 15

GnRH agonist, 治療子宮內膜異位造成的疼痛