06 Anti-osteoporesis Drugs

Question 1

Alendronate, Risedronate

Answer 1

FPP inhibitor
使 Osteoclast apoptosis
口服，GI disturbance，吃完不能馬上躺下來

Question 2

Pamidronate, Ibandronate

Answer 2

FPP inhibitor
I.V.
Osteonecrosis of the jaw (ONJ)

Question 3

Strontium ranelate

Answer 3

鍶類似物

模擬鈣，可直接當骨頭原料，也會抑制 Osteoclast，促進 Osteoblast

Question 4

Calcitonin salmon

Answer 4

Calcitonin

促進成骨細胞、抑制噬骨細胞

Question 5

Teriparatide

Answer 5

Recombinant human PTH

促進成骨細胞、增加鈣吸收

Question 6

Raloxifene

Answer 6

SERMs, ER agonist in bone

適合停經後婦女使用

Question 7

Denosumab

Answer 7

Anti-RANKL
RANKL: 成骨細胞分泌促進噬骨細胞成長的 Ligand，抑制後可以阻止噬骨細胞成長
Intrinsic anti-RANKL: OPG (Osteoprotegerin)

Question 8

Romosozumab

Answer 8

Anti-Sclerostin antibody
Sclerostin: 抑制 Wnt/β catenin pathway
Wnt/β catenin pathway : induces osteoblast pathway