1. MTB Step 3 - Antibiotics Flashcards
Cards Complete: Day 1: 4/19/19* Day 2: 4/22/19* Day 3: 4/29/19* Day 4: 5/19/19 Day 5: 6/18/19
What (4) Locations of the body does Staphylococcus aureus most commonly infect?
- Bone
- Heart
- Joint
- Skin
What are (3) IntraVenous (IV) Antibiotics used to treat SENSITIVE Staphylococcus aureus (MSSA) infection?
- Nafcillin (IV)
- Oxacillin (IV)
- Cefazolin (IV)
What are (2) Oral (PO) Antibiotics used to treat SENSITIVE Staphylococcus aureus (MSSA) infection?
- Dicloxacillin (PO)
- Cephalexin (PO)
Which Generation do the (2) Cephalosporins used to treat MSSA (Cefazolin IV and Cephalexin PO) belong to?
First-generation Cephalosporins (Cefazolin, Cephalexin)
What are (6) first-line Antibiotics used to treat SEVERE Methicillin-Resistant Staphylococcus aureus(MRSA)?
- Vancomycin
- Linezolid
- Daptomycin
- Ceftaroline
- Tigecycline
- Telavancin
Oritavancin, Telavancin, and Dalbavancin are L_ong-Acting Antibiotics_ (equal to Vancomycin) for the treatment of what?
Methicillin-Resistant Staphylococcus aureus (MRSA)
Which (2) Antibiotics treat both MRSA and Vancomycin-Resistant Enterococci (VRE)?
- Linezolid
- Tedizolid
What are (3) first-line Antibiotics used to treat MINOR Methicillin-Resistant Staphylococcus aureus(MRSA)?
- Trimethoprim/Sulphamethoxazole (TMP/SMX)
- Clindamycin
- Doxycycline
What are (2) Adverse Effects of Linezolid that are NOT found with Tedizolid?
- Interferes with MAO Inhibitors
- Thrombocytopenia (Low Platelets)
Myopathy and Rising CPK are Adverse Effects of which Antibiotic?
Daptomycin
Which Class of Antibiotics are SAFE to use as a Substitute in a patient who gets a Rash in response to taking Penicillin?
Cephalosporins
Which (_2_) Antibiotics should be used as a Substitute in a patient who gets Anaphylaxis in response to taking Penicillin?
- Clindamycin
- Linezolid
What are (4) Antibiotics used as a Substitute to treat MINOR Staphylococcus aureus infections in patients Allergic to Penicillin (rash or anaphylaxis)?
- Azithromycin
- Clarithromycin
- Clindamycin
- TMP/SMX
The following defines what Antibiotic mechanism?:
Antibiotics that Inhibit bacterial cell wall synthesis by binding to the D-Ala-D-Ala terminus of the peptidoglycan in the growing cell wall.
Bactericidal:
Examples: Telavancin, Dalbavancin, and Oritavancin
What Antibiotic has a MOA as a Folate Antagonist?
TMP/SMX
What is the MOA for the antibiotic Linezolid?
Inhibits Protein Synthesis
What is the MOA for All Cephalosporins?
They Inhibit cell wall growth by binding the penicillin-binding protein.
ALL of the same Antibiotics that are used to treat Staphylococcus Infections will also cover what other Types of Infections?
STREPTOCOCCUS Infections:
IV: Oxacillin/nafcillin, or cefazolin
Oral: Dicloxacillin or cephalexin
Minor infection: Trimethoprim/sulfamethoxazole (TMP/SMX), clindamycin, doxycycline
Severe infection: Vancomycin, Linezolid, Tedizolid, Daptomycin, Ceftaroline, Tigecycline, or Telavancin.
Long-Acting:Oritavancin, Telavancin, and Dalbavancin
In addition to All of the Antibiotics used to treat Staphylococcus Infections, what are (3) extra Antibiotics used to treat Streptococcus Infections?
- Penicillin
- Ampicillin
- Amoxicillin
Citrobacter**, **Enterobacter**, **Escherichia coli**, **Morganella**, **Pseudomonas, and Serratia are all in what category of Bacteria?
Gram-Negative Bacilli (Rods)
What are (2) Cephalosporins used to treat Infections from Gram-Negative Bacilli (Rods)?
- Cefepime
- Ceftazidime
What are (2) Penicillins used to treat Infections from Gram-Negative Bacilli (Rods) in addition to treating Streptococci and Anaerobes?
- Piperacillin
- Ticaracillin
What is (1) Monobactam used to treat Infections from Gram-Negative Bacilli (Rods)?
- Aztreonam
What are (4) Fluoroquinolones used to treat Infections from Gram-Negative Bacilli (Rods)?
- Ciprofloxacin
- Levofloxacin (excellent pneumococcal drug)
- Moxifloxacin (excellent pneumococcal drug)
- Gemifloxacin (excellent pneumococcal drug)
What are (3) Aminoglycosides used to treat Infections from Gram-Negative Bacilli (Rods) that also work synergistically with other agents to treat Staphylococcus and Enterococcus infections?
- Gentamicin
- Amikacin
- Tobramycin
What are (4) Carbapenems used to treat Infections from Gram-Negative Bacilli (Rods)?
- Imipenem
- Meropenem
- Ertapenem (only carbapenem that does not cover Pseudomonas)
- Doripenem
What (3) things do Carbapenems cover?
- Anaerobes (excellent coverage)
- Streptococci
- MSSA
What Antibiotic covers MRSA and is broadly active against Gram-Negative Bacilli (Rods)?
Tigecycline (weaker than other anti-MRSA antibiotics)
What Antibiotic is strongly active against MultiDrug-Resistant (MDR) Gram-Negative Bacilli (Rods)?
Polymyxin/Colistin
- Used because of Renal Toxicity
- Look for, “Failed therapy for Ventilator-Associated Pneumonia (VAP)” in case.