Zoonoses II Flashcards

1
Q

infective form of schistosoma

A

cercaria

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2
Q

respiration done by adult worms in schistosoma

A

anaerobic

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3
Q

clinical symptoms of acute infection with schistosoma mansoni and japonicum

A

katayama disease - rash, fever, myalgia

eosinophilia with hepatosplenomegaly

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4
Q

clinical symptoms of chronic infection with schistosoma mansoni and japonicum

A

eggs lodged in blood vessels of liver –> diarrhea, constipation, chronic inflammation, liver fibrosis

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5
Q

pathogenesis of schistosoma mansoni and japonicum

A

proteinases, collagenases, elastases

blockage of internal organs

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6
Q

how does the schistosoma avoid the immune system

A

concealment of antigenic sites and molecular mimicry

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7
Q

most common symptom of hookworms (ancyclostoma duodenale and necator americanus)

A

iron deficiency anemia followed by cardiac complications

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8
Q

infective form of hookworms (anyclostoma duodenale and necator americanus)

A

filariform - L3 larvae

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9
Q

immunopathogenesis of anyclostoma duodenale and necator americanus aka hookworms

A

protein losing enteropathies

type I autoimmune diseases

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10
Q

infective stage of strongyloides stercoralis

A

filariform - L3 larvae or autoinfection with perianal skin or GIT mucosa

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11
Q

manifestation of stronglyloide stercoralis

A

urticarial rash around thighs and buttocks (type I)
pulmonary symptoms
larva currens
blood eosinophilia
disseminated strongyloidiasis in immunosuppressed

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12
Q

pathogen in pasteurellosis and its characteristics

A

pasteurella multocida
gram neg short rods/short bacilli
oxidase positive
grows on enriched media like blood agar but not media selective for gram negs

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13
Q

what is pasteurellosis sensitive to

A

penicillin

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14
Q

how does one get infected with pasteurellosis

A

bite by dogs or scratch (sometimes human bite)

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15
Q

clinical syndrome and diagnosis of pasteurellosis

A

cellulitis

diagnose with culture from aspirated pus

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16
Q

pathogen in cat scratch disease and its characteristics

A

bartonella henselae

gram neg and facultative intracellular

17
Q

symptoms of cat scratch disease

A

fever and regional lymphadenopathy (head, neck, axilla)

18
Q

what does bartonella henselae cause in HIV patients

A

bacillary angiomatosis

19
Q

diseases caused by bartonella quintana an bartonella bacilliformis

A

quintana - trench fever

bacilliformis - oroya fever

20
Q

what is classified under ornithosis aka psittaci

A

chlamydophilia

21
Q

two forms of chlamydophilia psittaci and its function

A

elementary bodies - infective form and is metabolically inactive

reticulate bodies - noninfectious form and is metabolically active

22
Q

characteristics of chlamydophilia

A

no peptidoglycan in cell wall
contains lipopolysaccharide (it is gram neg intracellular)
major outer membrane protein (MOMP)
outer membrane protein (OMP)

23
Q

how does chlamydophilia replicate

A
  • elementary bodies attach to microvilli and penetrate into the cell
  • intact elementary bodies outer membrane inhibits fusion to lysosomes so no killing of chlamydia
  • EB reorganizes and becomes large metabolically active RBs
  • RBs then divide into smaller EBs rupturing the host cell
24
Q

how does one get chlamydophilia psittaci

A

inhalation of excreta, urine, or respiratory droplets from birds

25
Q

pulmonary symptoms of chlamydophilia psitacci aka parrot fever

A

non productive cough and consolidation

26
Q

pathogen in yersiniosis and its characteristics

A
yersinia pestis
gram negative
glucose fermenter
polysaccharide capsule
oxidase negative
27
Q

hosts for yersiniosis

A

rodents — they tend to get lymphohematogenous infection

28
Q

vector for yersiniosis

A

xenophylla cheopis which is rat flea

29
Q

how does one get exposed to yersiniosis

A

flea bite by the xenophylla cheopis

inhalation of droplets

30
Q

what do each form of the yersiniosis exposure lead to

A

flea bite - infected lymph node swells giving a bubo and then can progress to bacteremia

inhalation - pneumonic plague

31
Q

what does not work against the pneumonic plague

A

inactivated vaccine

32
Q

incubation of yersiniosis

A

bubo - 4 to 7 days

pneumonic - 18 to 36 hours

33
Q

what occurs if person gets the pneumonic form of yersiniosis

A

they get violent and fulminating bacterial pneumonia which is usually fatal

34
Q

those with descendants who survived the plague have heightened resistance against what

A

HIV

35
Q

if you are heterozygous for the gene that makes a defective CCR5 sequence, what benefit do you have

A

increased resistance against HIV

36
Q

if you are homozygous for the gene that makes a defective CCR sequence, what is the benefit

A

immune against HIV