Vasoactive Drugs - Epinephrine

Question 1

What is the appropriate dose range for an Epinephrine IV push in a 70 kg patient?
A) 5-10 mg
B) 5-10 mcg
C) 1-20 mcg
D) 50-100 mcg

Answer 1

B) 5-10 mcg

Question 2

What is the typical dose range for an Epinephrine IV infusion in a 70 kg patient?
A) 5-10 mcg/min
B) 10-30 mcg/min
C) 1-20 mcg/min
D) 0.5-1 mcg/min

Answer 2

C) 1-20 mcg/min

Question 3

Which of the following describes the concentration of Epinephrine in a standard vial?

A) 1 mg/mL
B) 10 mcg/mL
C) 100 mcg/mL
D) 0.1 mg/mL

Answer 3

A) 1 mg/mL

Question 4

What is the onset of action for Epinephrine when administered intravenously?
A) 1 minute
B) 5 minutes
C) 10 minutes
D) 30 seconds

Answer 4

A) 1 minute

Question 5

How long is the typical duration of action for Epinephrine after administration?

A) 1 minute
B) 5 minutes
C) 10 minutes
D) 30 minutes

Answer 5

B) 5 minutes

Question 5

What is the standard concentration of Epinephrine after diluting 1 mg in 100 mL?
A) 1 mcg/mL
B) 10 mcg/mL
C) 100 mcg/mL
D) 0.1 mg/mL

Answer 5

B) 10 mcg/mL

Concentration: 1mg/mL vial;
dilute 1mg in 100mL= 10mcg/mL

Question 5

What is the mechanism of action (MOA) of Epinephrine?
A) Direct Parasympathomimetic
B) Indirect Sympathomimetic
C) Direct Sympathomimetic
D) Alpha-2 Agonist

Answer 5

C) Direct Sympathomimetic

Question 6

What is known about the excretion of Epinephrine?
A) It is excreted via urine
B) It is excreted via bile
C) It is excreted through sweat
D) The excretion pathway is unknown

Answer 6

Answer: D) The excretion pathway is unknown

Question 7

How is Epinephrine primarily metabolized?

A) Via the kidneys
B) Via the lungs
C) Via the liver
D) Via the spleen

Answer 7

C) Via the liver

Question 8

What is the half-life of Epinephrine?
A) 10 minutes
B) 1 hour
C) 2 hours
D) 4 hours

Answer 8

C) 2 hours

Question 9

Which of the following statements are true regarding the comparison between 10 mcg of Epinephrine and 10 mg of Ephedrine? (Select all that apply)

A) Both Epinephrine and Ephedrine are direct sympathomimetics.

B) Epinephrine has a faster onset of action compared to Ephedrine.

C) Ephedrine has a longer duration of action compared to Epinephrine.

D) Epinephrine works primarily by releasing stored norepinephrine.

E) 10 mcg of Epinephrine has a similar effect to 10 mg of Ephedrine on increasing blood pressure.
Answers:

Answer 9

B) Epinephrine has a faster onset of action compared to Ephedrine.

C) Ephedrine has a longer duration of action compared to Epinephrine.

E) 10 mcg of Epinephrine has a similar effect to 10 mg of Ephedrine on increasing blood pressure.

Question 9

Action:
alpha +
beta1 ++
beta2 ++
CO ++
HR ++
Dysrhythmias +++

Question 10

Which of the following is a contraindication to the use of Epinephrine?
A) Patients on beta-blockers
B) Patients on ACE inhibitors
C) Patients on Monoamine Oxidase Inhibitors (MAOIs)
D) Patients with asthma

Answer 10

C) Patients on Monoamine Oxidase Inhibitors (MAOIs)

Question 11

What precaution should be considered when administering Epinephrine?

A) Epinephrine should not be used in hypertensive patients.
B) Epinephrine should be avoided in patients with bradycardia.
C) Hypertension should be monitored, but there are no absolute precautions due to the emergent need for Epinephrine.
D) Epinephrine should only be administered with a loading dose.

Answer 11

C) Hypertension should be monitored, but there are no absolute precautions due to the emergent need for Epinephrine.

Question 11

What is a common side effect associated with the use of Epinephrine?
A) Bradycardia
B) Hypotension
C) Arrhythmias
D) Muscle weakness

Answer 11

C) Arrhythmias