Narcotics - Morphine Flashcards
- What is the typical dose range for Morphine for post-operative pain when administered intravenously (IV)?
A. 2-10 mg IV
B. 5-20 mg IV
C. 10-30 mg IV
D. 15-25 mg IV
B. 5-20 mg IV
TxWes
Dose: 1-10 mg IV
IM & IV Onset: 10-20 mins.
IM Peak: 45 to 90 minutes
IV Peak: 15 to 30 mins
Duration: 4-5 hours
PO Hepatic 1st Pass: 25%.
No first pass uptake in lungs
Accumulates rapidly in kidneys, liver, and skeletal muscles.
- For maintenance of post-operative pain, what is the recommended Morphine dose range administered IV per hour?
A. 0.5-1 mg/hr IV
B. 1-2 mg/hr IV
C. 2-4 mg/hr IV
D. 5-10 mg/hr IV
B. 1-2 mg/hr IV
- What is the primary action of Morphine on opioid receptors?
A. Mu1-R
B. Kappa-R
C. Delta-R
D. Sigma-R
A. Mu1-R
Suppress pain through primary action on mu1-R, then kappa and delta opioid-Rs. Directly inhibit ascending nociceptive presynaptic transmission of excitatory NTs, and activation of descending inhibitory pain pathway.
What is the concentration of Morphine solution when it is prepared for IV administration?
A. 0.5 mg/mL
B. 1 mg/mL
C. 2 mg/mL
D. 5 mg/mL
B. 1 mg/mL
What is the onset of Morphine typically begin to exert its effects after intravenous administration?
A. 1 minute
B. 3 minutes
C. 10 minutes
D. 30 minutes
B. 3 minutes
B. 3 minutes
Tx Wes Reference
10-20 min
What is the peak effect time for Morphine after intravenous administration?
A. 5 minutes
B. 10 minutes
C. 15 minutes
D. 30 minutes
C. 15 minutes
What is the typical duration of action for Morphine?
A. 30 minutes to 1 hour
B. 1-2 hours
C. 2-4 hours
D. 4-6 hours
C. 2-4 hours
Tx Wes Reference:
4-5 hr
- What is the half-life of Morphine?
A. 1 hour
B. 2 hours
C. 3 hours
D. 4 hours
C. 3 hours
Morphine is primarily metabolized through which process?
A. Oxidation in the liver
B. Glucuronic acid conjugation
C. Hydrolysis in the plasma
D. Reduction in the kidneys
B. Glucuronic acid conjugation
What are the primary metabolites of Morphine formed through glucuronic acid conjugation?
A. M1G and M2G
B. M3G and M6G
C. M5G and M7G
D. M4G and M8G
B. M3G and M6G
- What percentage of Morphine undergoes first-pass metabolism in the lungs?
A. 25%
B. 50%
C. 75%
D. 90%
C. 75%
How is Morphine primarily eliminated from the body?
A. Fecal excretion
B. Renal excretion
C. Pulmonary excretion
D. Biliary excretion
B. Renal excretion
Morphine belongs to which chemical class?
A. Benzodiazepine
B. Phenanthrene
C. Phenylbutazone
D. Cyclooxygenase inhibitor
B. Phenanthrene
Morphine is known to increase the production of which hormone?
A. Insulin
B. Cortisol
C. Antidiuretic hormone (ADH)
D. Thyroid-stimulating hormone (TSH)
C. Antidiuretic hormone (ADH)
What is a notable characteristic of Morphine that affects its interaction with the body?
A. It is hydrophilic.
B. It is lipophilic.
C. It has a high protein-binding capacity.
D. It has a low first-pass metabolism.
A. It is hydrophilic
For which type of pain is Morphine generally more effective?
A. Sharp, acute pain
B. Neuropathic pain
C. Dull pain, particularly in pre and post-operative settings
D. Migraines
C. Dull pain, particularly in pre and post-operative settings
Which of the following is a common precaution when administering Morphine?
A. Increased risk of tachycardia
B. Risk of histamine release
C. Risk of hyperglycemia
D. Risk of increased blood pressure
B. Risk of histamine release
When prescribing Morphine to elderly patients, what adjustment is commonly recommended?
A. Increase the dose
B. Decrease the dose
C. No dose adjustment needed
D. Administer more frequently
B. Decrease the dose
Which side effect of Morphine is associated with a risk of respiratory complications?
A. Constipation
B. Depression of ventilation (including laryngospasms)
C. Itching
D. Nausea and vomiting
B. Depression of ventilation (including laryngospasms)
Morphine can cause a decrease in which reflexes that are important for maintaining blood pressure?
A. Baroreceptor reflex and carotid sinus reflex
B. Vestibular reflex and ocular reflex
C. Cough reflex and gag reflex
D. Pupillary reflex and corneal reflex
A. Baroreceptor reflex and carotid sinus reflex
What are other side effects of Morphine?
A. bradycardia,
B. HoTN,
C. myoclonus,
D. N/V,
E. itching,
F.constipation
G. All of the Above
G. All of the Above
