Narcotics - Fentanyl Flashcards
Sufentanil (1000x)>
Fentanyl=Remifentanil (100x)>
Alfentanil (20x)>
Dilaudid (5x)>
Morphine
What is the typical dose range of Fentanyl for analgesia or sympathetic block during induction in adults?
A. 0.5-1 mcg/kg IV
B. 1-2 mcg/kg IV
C. 2-3 mcg/kg IV
D. 3-4 mcg/kg IV
B. 1-2 mcg/kg IV
TxWes
Cardiopulmonary Bypass?
Analgesia: 1 to 2 µg/kg IV
Induction: 1.5 to 3 µg/kg IV 5 mins prior
Adjunct with inhaled anesthetics:
2 to 20 µg/kg IV
Direct laryngoscopy during intubation
Sudden changes in surgical stimulation level
Tx Wes Reference:
1.5-3 mcg/kg
When using Fentanyl as an adjunct with inhaled anesthetics, what is the recommended dose range?
A. 5-10 mcg
B. 12.5-50 mcg
C. 50-75 mcg
D. 75-100 mcg
B. 12.5-50 mcg
(used during DL and sudden changes in sx stimulation level)
TxWes
Cardiopulmonary Bypass?
Analgesia: 1 to 2 µg/kg IV
Induction: 1.5 to 3 µg/kg IV 5 mins prior
Adjunct with inhaled anesthetics:
2 to 20 µg/kg IV
Direct laryngoscopy during intubation
Sudden changes in surgical stimulation level
What is the concentration of Fentanyl typically available in vials for intravenous administration?
A. 10 mcg/mL
B. 25 mcg/mL
C. 50 mcg/mL
D. 100 mcg/mL
C. 50 mcg/mL
What is the primary receptor through which Fentanyl exerts its analgesic effects?
A. Alpha-1 adrenergic receptor
B. Mu-1 opioid receptor
C. Beta-2 adrenergic receptor
D. NMDA receptor
B. Mu-1 opioid receptor
then kappa and delta opioid-Rs.
In addition to the mu-1 opioid receptor, which other opioid receptors does Fentanyl interact with?
A. Alpha-1 and beta-2 adrenergic receptors
B. Kappa and delta opioid receptors
C. NMDA and GABA receptors
D. Serotonin and dopamine receptors
Answer: B. Kappa and delta opioid receptors
Fentanyl’s mechanism of action involves the activation of which type of pain pathway?
A. Ascending excitatory pain pathway
B. Descending inhibitory pain pathway
C. Peripheral nociceptive pain pathway
D. Central sensory processing pathway
Answer: B. Descending inhibitory pain pathway
What is the typical onset time for Fentanyl when administered intravenously?
A. 30 seconds
B. 1-3 minutes
C. 5 minutes
D. 10 minutes
Answer: B. 1-3 minutes
high lipid soluble (potent);
Tx Wes Reference:
30-60 sec
To achieve peak effect during rapid sequence induction (RSI) with Fentanyl, how many minutes before induction should it be administered?
A. Immediately before induction
B. 1 minute before induction
C. 3 minutes before induction
D. 5 minutes before induction
Answer: C. 3 minutes before induction
What is the typical duration of action for Fentanyl?
A. 10-20 minutes
B. 20-30 minutes
C. 30-60 minutes
D. 60-90 minutes
C. 30-60 minutes
Tx Wes Reference:
1-1.5 hr
What is the elimination half-life (1/2) of Fentanyl?
A. 1-2 hours
B. 2-4 hours
C. 3-6 hours
D. 6-8 hours
C. 3-6 hours
What is the context-sensitive half-life of Fentanyl, which reflects its clearance after prolonged infusions?
A. 60 minutes
B. 120 minutes
C. 180 minutes
D. 260 minutes
D. 260 minutes
Which statement is true regarding the effects of continuous intravenous administration of Fentanyl?
A. Continuous IV administration of Fentanyl decreases its effects over time.
B. Continuous IV administration of Fentanyl yields greater effects as the duration of infusion increases.
C. Continuous IV administration of Fentanyl has no effect on its overall efficacy.
D. Continuous IV administration of Fentanyl leads to a plateau in effects regardless of duration.
Answer:
B. Continuous IV administration of Fentanyl yields greater effects as the duration of infusion increases.
Among Fentanyl, Alfentanil, Sufentanil, and Remifentanil, which opioid has the highest context-sensitive half-life (CSHL)?
A. Alfentanil
B. Fentanyl
C. Sufentanil
D. Remifentanil
Answer:
B. Fentanyl
Which opioid has the lowest context-sensitive half-life among the following?
A. Fentanyl
B. Alfentanil
C. Sufentanil
D. Remifentanil
Answer:
D. Remifentanil