Downers - Hydralazine

Question 1

What is the typical dose range of Hydralazine for adults when administered intravenously?
(Select all that apply)

A. 1-5 mg every 4 hours
B. 5-20 mg every 4 hours
C. 10-15 mg every 4 hours
D. 5-20 mg every 6 hours

Answer 1

B. 5-20 mg every 4 hours

Adult: 5-20 mg IV Q4H (start with 5 mg since the onset takes so long)

Question 2

What is the appropriate dosing range for Hydralazine in pediatric patients?
(Select all that apply)

A. 0.1-0.2 mg/kg every 2 hours
B. 0.1-0.2 mg/kg every 4 hours
C. 5-10 mg every 4 hours
D. 0.1-0.2 mg/kg every 6 hours

Answer 2

B. 0.1-0.2 mg/kg every 4 hours

Question 3

For managing pregnancy-induced hypertension, what is the recommended dose of Hydralazine?
(Select all that apply)

A. 5-10 mg IV every 30 minutes
B. 5-20 mg IV every 30 minutes
C. 5-10 mg IV every hour
D. 5-10 mg IV every 4 hours

Answer 3

A. 5-10 mg IV every 30 minutes

Question 4

What is the concentration of Hydralazine in its injectable form?
(Select all that apply)

A. 10 mg/mL
B. 20 mg/mL
C. 50 mg/mL
D. 5 mg/mL

Answer 4

B. 20 mg/mL

Question 5

Which of the following effects does Hydralazine have on the vascular system?
(Select all that apply)

A. Direct decrease in arterial smooth muscle tone
B. Direct decrease in venous smooth muscle tone
C. Unclear mechanism possibly involving N2O release
D. Significant increase in arterial smooth muscle tone

Answer 5

A. Direct decrease in arterial smooth muscle tone
C. Unclear mechanism possibly involving N2O release

MOA: Unclear (N2O release?), but causes direct dec in vascular smooth muscle tone (arterial > venous)

Question 6

What is the typical onset time for Hydralazine when administered intravenously?
(Select all that apply)

A. 1-5 minutes
B. 5-20 minutes
C. 30 minutes
D. 1 hour

Answer 6

B. 5-20 minutes

Onset: 5-20 minutes IV (slow onset! Be patient before you give more);

Question 7

What is the usual duration of effect for Hydralazine?
(Select all that apply)

A. 30 minutes
B. 1-2 hours
C. 2-6 hours
D. 6-8 hours

Answer 7

C. 2-6 hours

Question 8

What is the half-life of Hydralazine?
(Select all that apply)

A. 1-2 hours
B. 3-7 hours
C. 8-10 hours
D. 12 hours

Answer 8

B. 3-7 hours

Question 9

Which of the following conditions is Hydralazine indicated for?
(Select 3)

A. Hypertension (HTN)
B. Pregnancy-induced hypertension (PIH)
C. Congestive heart failure (CHF)
D. Hyperglycemia

Answer 9

A. Hypertension (HTN)
B. Pregnancy-induced hypertension (PIH)
C. Congestive heart failure (CHF)

Question 9

How is Hydralazine primarily eliminated from the body?
(Select all that apply)

A. Hepatic metabolism
B. Renal excretion
C. Pulmonary excretion
D. Fecal elimination

Answer 9

A. Hepatic metabolism
B. Renal excretion

Question 10

What is a notable action of Hydralazine in relation to renal and splanchnic blood flow?
(Select 2)

A. Hydralazine helps to maintain renal blood flow.
B. Hydralazine maintains splanchnic blood flow.
C. Hydralazine decreases renal blood flow.
D. Hydralazine has no effect on splanchnic blood flow.

Answer 10

A. Hydralazine helps to maintain renal blood flow.
B. Hydralazine maintains splanchnic blood flow.

maintains renal and splanchnic BF, use if HR low

Question 11

What is a significant precaution to consider when administering Hydralazine?
(Select 2)

A. Hydralazine acts as a potent cerebral vasodilator and may increase intracranial pressure (ICP).
B. Hydralazine has no effect on intracranial pressure.
C. Hydralazine should be avoided in patients with high ICP.
D. Hydralazine should be used without regard to potential effects on cerebral vasculature.

Answer 11

A. Hydralazine acts as a potent cerebral vasodilator and may increase intracranial pressure (ICP).

C. Hydralazine should be avoided in patients with high ICP.

Question 12

Which of the following are potential side effects of Hydralazine?
(Select all that apply)

A. Hypotension
B. Reflex tachycardia
C. Lupus
D. Thrombophlebitis
E. All of the above

Answer 12

E. All of the above