Reversal Agents - Naloxone (Narcan) Flashcards
What is the typical bolus dose range for Naloxone (Narcan) when used intravenously to reverse respiratory depression?
A) 0.5-2 mcg/kg
B) 1-4 mcg/kg
C) 5-10 mcg/kg
D) 10-20 mcg/kg
B) 1-4 mcg/kg
What is the typical dose of Naloxone (Narcan) used to reverse respiratory depression without affecting analgesia?
A) 5-10 mcg
B) 10-20 mcg
C) 20-40 mcg
D) 40-60 mcg
Answer: C) 20-40 mcg
TxWes Reference
40 - 80 mcg
onset: 1 - 5 min
duration: 30 min
What is the continuous infusion dose of Naloxone (Narcan) when administered intravenously?
A) 1 mcg/kg/hr
B) 2 mcg/kg/hr
C) 5 mcg/kg/hr
D) 10 mcg/kg/hr
Answer: C) 5 mcg/kg/hr
Given a concentration of 0.4 mg of Naloxone in 10 mL, what is the concentration in mcg/mL?
A) 20 mcg/mL
B) 30 mcg/mL
C) 40 mcg/mL
D) 50 mcg/mL
Answer: C) 40 mcg/mL
What is the “shock dose” of Naloxone (Narcan) administered intravenously?
A) 0.5 mg/kg
B) 1 mg/kg
C) 2 mg/kg
D) 5 mg/kg
Answer: B) >1 mg/kg
What is the mechanism of action (MOA) of Naloxone (Narcan)?
A) Selective agonist for μ-opioid receptors
B) Nonselective antagonist at all opioid receptors in the CNS
C) Partial agonist at κ-opioid receptors
D) Selective antagonist for δ-opioid receptors
Answer: B) Nonselective antagonist at all opioid receptors in the CNS
What is the typical onset time for Naloxone (Narcan) when administered?
A) 30 seconds
B) 1-2 minutes
C) 5 minutes
D) 10 minutes
B) 1-2 minutes
What is the duration of action for Naloxone (Narcan) after a single dose?
A) 5-10 minutes
B) 15-20 minutes
C) 30 minutes
D) 60 minutes
Answer: C) 30 minutes
Onset: 1-2 minutes onset for duration of 30 minutes (redose)
How is Naloxone (Narcan) primarily metabolized in the body?
A) By hepatic oxidation
B) By plasma esterases
C) By glucuronidation to naloxone-3-glucuronide
D) By renal filtration
Answer: C) By glucuronidation to naloxone-3-glucuronide
What is the primary route of elimination for Naloxone (Narcan)?
A) Fecal elimination
B) Biliary excretion
C) Urinary elimination
D) Sweating
C) Urinary elimination
What is the half-life (t½) of Naloxone (Narcan)?
A) 15-30 minutes
B) 30-60 minutes
C) 60-120 minutes
D) 120-180 minutes
C) 60-120 minutes
What is one of the primary actions of Naloxone (Narcan)?
A) Induction of anesthesia
B) Reversal of post-operative respiratory depression
C) Sedation for surgical procedures
D) Analgesia enhancement
B) Reversal of post-operative respiratory depression
Naloxone (Narcan) is used in neonates to reverse the effects of:
A) Hypoglycemia
B) Opioid overdose if the mother had opioids, pruritus, urinary retention, muscle rigidity, and biliary spasm.
C) Respiratory distress unrelated to opioids
D) Hyperbilirubinemia
B) Opioid overdose if the mother had opioids, pruritus, urinary retention, muscle rigidity, and biliary spasm.
What is a contraindication for the use of Naloxone (Narcan)?
A) Reversal of opioid-induced constipation
B) Reversal of opioid-induced pruritus
C) Reversal of buprenorphine analgesia, which will reverse pain but not respiratory depression, potentially causing withdrawal symptoms
D) Reversal of opioid-induced nausea
Answer: C) Reversal of buprenorphine analgesia, which will reverse pain but not respiratory depression, potentially causing withdrawal symptoms
C/I: Reversal of buprenorphine analgesia will reverse pain but not resp depression, causing withdrawals.
What cardiovascular effect can Naloxone (Narcan) have?
A) Decrease in sympathetic nervous system (SNS) tone
B) Increase in sympathetic nervous system (SNS) tone
C) Induction of bradycardia
D) Reduction in blood pressure
Answer: B) Increase in sympathetic nervous system (SNS) tone
