Inhaled Anesthetics - Desflurane (Not used at ARMC, but other facilities may have) Flashcards
Which of the following statements accurately describes the chemical structure of Desflurane? (Select 3)
A) Desflurane is an ether with the structure R-O-R’
B) Desflurane exists as a gas at standard temperature and pressure (STP)
C) Desflurane has 6 fluoride ions in its structure
D) Desflurane contains 4 chlorine atoms
E) Desflurane is a liquid at standard temperature and pressure (STP)
A) Desflurane is an ether with the structure R-O-R’
C) Desflurane has 6 fluoride ions in its structure
E) Desflurane is a liquid at standard temperature and pressure (STP)
What is the MAC (Minimum Alveolar Concentration) of Desflurane?
A) 1.2%
B) 2.5%
C) 3.5%
D) 6.6%
E) 8.0%
D) 6.6%
Which of the following statements correctly describes the Blood
Partition Coefficient of Desflurane? (Select 2)
A) It has a Blood Partition Coefficient of 0.42
B) This low coefficient indicates a fast onset of action
C) A high Blood Partition Coefficient would indicate a fast onset
D) Desflurane is the most soluble in blood among inhalational anesthetics
E) It has the slowest onset of action among inhalational anesthetics
A) It has a Blood
Partition Coefficient of 0.42
B) This low coefficient indicates a fast onset of action
Blood:Gas Partition Coefficient (onset): 0.42 (least soluble in blood = fastest onset)
What is the primary mechanism of action (MOA) of Desflurane in the brain?
A) GABAA receptor modulation
B) NMDA receptor activation
C) Inhibition of Na+ channels
D) Potentiation of K+ channels
E) Glycine receptor activation
A) GABAA receptor modulation
GABAA (MAIN–Increased frequency/duration of Cl- pore opening–inhibits NT release presynaptically to decrease membrane potential post-synaptically) BRAIN
Which of the following mechanisms contribute to Desflurane’s anesthetic effects in the spinal cord? (Select 4)
A) GABAA receptor modulation
B) Glycine receptor stimulation
C) NMDA receptor inhibition
D) Na+ channel inhibition
E) K+ channel potentiation
B) Glycine receptor stimulation
C) NMDA receptor inhibition
D) Na+ channel inhibition
E) K+ channel potentiation
-Glycine-R stimulation, NMDA-R inhibition, Na+ channel inhibition, & K+ Channel Potentiation in SPINAL CORD to produce immobility in ventral horn (NOT d/t GABAA)
The half-life of Desflurane is primarily dependent on which physiological parameters? (Select 2)
A) Cardiac output
B) Lung function
C) Blood volume
D) Hepatic metabolism
E) Renal clearance
A) Cardiac output
B) Lung function
Which factors predominantly influence the half-life of Desflurane? (Select 2)
A) Cardiac Output (CO)
B) Minute Ventilation (Vm)
C) Renal Clearance
D) Hepatic Metabolism
E) Tissue Solubility
A) Cardiac Output (CO)
B) Minute Ventilation (Vm)
Which of the following correctly describes the elimination of Desflurane? (Select 3)
A) 99.82% is eliminated through the alveoli.
B) 0.02% is eliminated via hepatic biotransformation.
C) Percutaneous loss is nearly 0% of elimination.
D) Hepatic biotransformation accounts for the majority of Desflurane’s elimination.
E) Alveolar elimination is nearly complete, with minimal hepatic metabolism.
A) 99.82% is eliminated through the alveoli.
B) 0.02% is eliminated via hepatic biotransformation.
C) Percutaneous loss is nearly 0% of elimination.
Action:
SVR -,
HR ++,
CVP +,
SV -,
prolongation of QT interval
Which of the following are contraindications for the use of Desflurane? (Select 2)
A) Airway diseases due to increased reactivity and irritation
B) Induction of anesthesia (don’t use to induce)
C) Patients with a history of malignant hyperthermia
D) Use in pregnant patients
E) Biliary obstruction
A) Airway diseases due to increased reactivity and irritation
B) Induction of anesthesia (don’t use to induce)
What is a significant chemical interaction of Desflurane with dehydrated soda lime?
A) Production of Carbon Monoxide
B) Formation of Compound A
C) Formation of Nitrous Oxide
D) Production of Chlorine gas
E) Formation of Hydrochloric Acid
A) Production of Carbon Monoxide
Which of the following effects can occur due to overpressurization of Desflurane? (Select 2)
A) Decrease in blood pressure
B) Increase in heart rate
C) Decrease in heart rate
D) Increase in blood pressure
E) Decrease in respiratory rate
B) Increase in heart rate
D) Increase in blood pressure
Which of the following are common side effects associated with the use of Desflurane?
A) Postoperative nausea and vomiting (PONV)
B) Malignant hyperthermia (MH)
C) Postoperative shivering
D) Bradycardia
E) Hypertension
A) Postoperative nausea and vomiting (PONV)
B) Malignant hyperthermia (MH)
C) Postoperative shivering
