Antiemetics - Metoclopamide (Reglan) Flashcards
True or False: Metoclopramide (Reglan) is commonly used at ARMC.
False
What is the typical dose range for Metoclopramide (Reglan) administered IV?
A) 5-10 mg every 6 hours
B) 10-20 mg every 6 hours
C) 20-30 mg every 6 hours
D) 30-40 mg every 6 hours
B) 10-20 mg every 6 hours
10-20 mg IV over 3-5 min Q6
How should Metoclopramide (Reglan) be administered before induction?
A) 5 minutes prior to induction
B) 15-30 minutes prior to induction
C) 1 hour prior to induction
D) Immediately before induction
B) 15-30 minutes prior to induction
Metoclopramide (Reglan) is usually administered in combination with which of the following medications?
A) Ondansetron
B) Pepcid
C) Lorazepam
D) Hydrocodone
B) Pepcid
What is the concentration of Metoclopramide (Reglan) in its intravenous (IV) formulation?
A) 1 mg/mL
B) 2 mg/mL
C) 5 mg/mL
D) 10 mg/mL
C) 5 mg/mL
What is the primary mechanism of action (MOA) of Metoclopramide (Reglan)?
A) Serotonin receptor antagonist
B) Dopamine receptor antagonist
C) Alpha-2 agonist
D) COX-2 inhibitor
B) Dopamine receptor antagonist
MOA: Dopamine receptor antagonist even in the CNS
In addition to its central dopamine receptor antagonism, Metoclopramide (Reglan) has which of the following effects?
A) GI prokinetic effects
B) Vasoconstriction
C) Antihistaminic effects
D) Anticholinergic effects
Answer: A) GI prokinetic effects
How does Metoclopramide (Reglan) produce its GI prokinetic effects?
A) By antagonizing dopamine receptors in the CNS
B) By stimulating selective cholinergic activity in the upper GI tract
C) By inhibiting serotonin receptors in the GI tract
D) By blocking COX-1 enzymes
Answer: B) By stimulating selective cholinergic activity in the upper GI tract
How does Metoclopramide (Reglan) affect upper gastric motility? (Select 3)
A) It increases lower esophageal sphincter tone.
B) It stimulates upper gastric motility.
C) It relaxes the pylorus and duodenum, thereby increasing transit time.
D) It inhibits upper gastric motility.
A) It increases lower esophageal sphincter tone.
B) It stimulates upper gastric motility.
C) It relaxes the pylorus and duodenum, thereby increasing transit time.
stimulates upper gastric motility→ increases lower esophageal sphincter tone & increases transit time by relaxing pylorus and duodenum
Kane Preop Meds:
-Stimulates gastric motility (prokinetic)
Increases lower esophageal sphincter tone
-Stimulates peristalsis
-Relaxes pylorus and duodenum
Gastric emptying and intestinal transit
-Antagonizes dopamine receptors
-Not administered to patients with dopamine depletion/inhibition
-Extrapyramidal reactions (easily crosses BBB)
-Orthostatic hypotension
-Some effects on chemoreceptor trigger zone (Esp cinv and s/p csection but < 5-Ht3 drugs)
-No change in gastric ph
Which of the following effects is caused by Metoclopramide (Reglan) in the gastrointestinal system? (Select 3)
A) Increased lower esophageal sphincter tone
B) Increased gastric motility
C) Relaxation of the pylorus and duodenum
D) Decreased gastric emptying time
A) Increased lower esophageal sphincter tone,
B) Increased gastric motility,
C) Relaxation of the pylorus and duodenum
*MOA: Dopamine receptor antagonist even in the CNS. GI Prokinetic and produces selective cholinergic stimulation of the upper GI tract. stimulates upper gastric motility→ increases lower esophageal sphincter tone & increases transit time by relaxing pylorus and duodenum *
How does Metoclopramide (Reglan) exert its antiemetic and anti-nausea effects?
A) By antagonizing serotonin receptors in the chemoreceptor trigger zone
B) By antagonizing dopamine receptors in the chemoreceptor trigger zone
C) By stimulating histamine receptors in the vestibular system
D) By inhibiting acetylcholine receptors in the gastrointestinal tract
Answer: B) By antagonizing dopamine receptors in the chemoreceptor trigger zone
What is the onset time of Metoclopramide (Reglan) when administered intravenously?
A) 1 minute
B) 3 minutes
C) 5 minutes
D) 10 minutes
B) 3 minutes
Tx Wes Reference:
onset: 10 - 20 min
duration: 2 hr
What is the typical duration of action for Metoclopramide (Reglan)?
A) 30 minutes
B) 1-2 hours
C) 3-4 hours
D) 6-8 hours
B) 1-2 hours
Tx Wes Refernce:
2 hr
The elimination half-life of Metoclopramide (Reglan) is approximately:
A) 2 hours
B) 4 hours
C) 6 hours
D) 8 hours
C) 6 hours
Which receptor does Metoclopramide (Reglan) primarily antagonize to exert its effects?
A) Dopamine-2 receptor
B) Serotonin receptor
C) Histamine receptor
D) Alpha-1 receptor
A) Dopamine-2 receptor (prokinetic)