Antiemetics - Metoclopamide (Reglan) Flashcards

1
Q

True or False: Metoclopramide (Reglan) is commonly used at ARMC.

A

False

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2
Q

What is the typical dose range for Metoclopramide (Reglan) administered IV?

A) 5-10 mg every 6 hours

B) 10-20 mg every 6 hours

C) 20-30 mg every 6 hours

D) 30-40 mg every 6 hours

A

B) 10-20 mg every 6 hours

10-20 mg IV over 3-5 min Q6

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3
Q

How should Metoclopramide (Reglan) be administered before induction?

A) 5 minutes prior to induction

B) 15-30 minutes prior to induction

C) 1 hour prior to induction

D) Immediately before induction

A

B) 15-30 minutes prior to induction

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4
Q

Metoclopramide (Reglan) is usually administered in combination with which of the following medications?

A) Ondansetron

B) Pepcid

C) Lorazepam

D) Hydrocodone

A

B) Pepcid

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5
Q

What is the concentration of Metoclopramide (Reglan) in its intravenous (IV) formulation?

A) 1 mg/mL

B) 2 mg/mL

C) 5 mg/mL

D) 10 mg/mL

A

C) 5 mg/mL

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6
Q

What is the primary mechanism of action (MOA) of Metoclopramide (Reglan)?

A) Serotonin receptor antagonist

B) Dopamine receptor antagonist

C) Alpha-2 agonist

D) COX-2 inhibitor

A

B) Dopamine receptor antagonist

MOA: Dopamine receptor antagonist even in the CNS

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7
Q

In addition to its central dopamine receptor antagonism, Metoclopramide (Reglan) has which of the following effects?

A) GI prokinetic effects

B) Vasoconstriction

C) Antihistaminic effects

D) Anticholinergic effects

A

Answer: A) GI prokinetic effects

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8
Q

How does Metoclopramide (Reglan) produce its GI prokinetic effects?

A) By antagonizing dopamine receptors in the CNS

B) By stimulating selective cholinergic activity in the upper GI tract

C) By inhibiting serotonin receptors in the GI tract

D) By blocking COX-1 enzymes

A

Answer: B) By stimulating selective cholinergic activity in the upper GI tract

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9
Q

How does Metoclopramide (Reglan) affect upper gastric motility? (Select 3)

A) It increases lower esophageal sphincter tone.

B) It stimulates upper gastric motility.

C) It relaxes the pylorus and duodenum, thereby increasing transit time.

D) It inhibits upper gastric motility.

A

A) It increases lower esophageal sphincter tone.

B) It stimulates upper gastric motility.

C) It relaxes the pylorus and duodenum, thereby increasing transit time.

stimulates upper gastric motility→ increases lower esophageal sphincter tone & increases transit time by relaxing pylorus and duodenum

Kane Preop Meds:
-Stimulates gastric motility (prokinetic)
Increases lower esophageal sphincter tone
-Stimulates peristalsis
-Relaxes pylorus and duodenum
Gastric emptying and intestinal transit

-Antagonizes dopamine receptors
-Not administered to patients with dopamine depletion/inhibition
-Extrapyramidal reactions (easily crosses BBB)
-Orthostatic hypotension
-Some effects on chemoreceptor trigger zone (Esp cinv and s/p csection but < 5-Ht3 drugs)
-No change in gastric ph

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9
Q

Which of the following effects is caused by Metoclopramide (Reglan) in the gastrointestinal system? (Select 3)

A) Increased lower esophageal sphincter tone

B) Increased gastric motility

C) Relaxation of the pylorus and duodenum

D) Decreased gastric emptying time

A

A) Increased lower esophageal sphincter tone,
B) Increased gastric motility,
C) Relaxation of the pylorus and duodenum

*MOA: Dopamine receptor antagonist even in the CNS. GI Prokinetic and produces selective cholinergic stimulation of the upper GI tract. stimulates upper gastric motility→ increases lower esophageal sphincter tone & increases transit time by relaxing pylorus and duodenum *

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10
Q

How does Metoclopramide (Reglan) exert its antiemetic and anti-nausea effects?

A) By antagonizing serotonin receptors in the chemoreceptor trigger zone

B) By antagonizing dopamine receptors in the chemoreceptor trigger zone

C) By stimulating histamine receptors in the vestibular system

D) By inhibiting acetylcholine receptors in the gastrointestinal tract

A

Answer: B) By antagonizing dopamine receptors in the chemoreceptor trigger zone

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11
Q

What is the onset time of Metoclopramide (Reglan) when administered intravenously?

A) 1 minute

B) 3 minutes

C) 5 minutes

D) 10 minutes

A

B) 3 minutes

Tx Wes Reference:
onset: 10 min
duration: 2 hr

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12
Q

What is the typical duration of action for Metoclopramide (Reglan)?

A) 30 minutes

B) 1-2 hours

C) 3-4 hours

D) 6-8 hours

A

B) 1-2 hours

Tx Wes Refernce:
2 hr

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13
Q

The elimination half-life of Metoclopramide (Reglan) is approximately:

A) 2 hours

B) 4 hours

C) 6 hours

D) 8 hours

A

C) 6 hours

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14
Q

Which receptor does Metoclopramide (Reglan) primarily antagonize to exert its effects?

A) Dopamine-2 receptor

B) Serotonin receptor

C) Histamine receptor

D) Alpha-1 receptor

A

A) Dopamine-2 receptor (prokinetic)

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15
Q

Metoclopramide (Reglan) should be avoided in patients with which of the following conditions? (Select 3)

A) Parkinsonism

B) Seizure disorder

C) Mild gastrointestinal discomfort

D) Gastrointestinal obstruction

A

A) Parkinsonism,
B) Seizure disorder,
D) Gastrointestinal obstruction

15
Q

Which of the following conditions is a contraindication for the use of Metoclopramide (Reglan)?

A) Extrapyramidal symptoms

B) Mild nausea

C) Allergic reactions

D) Gastroesophageal reflux disease (GERD)

A

A) Extrapyramidal symptoms

16
Q

Select all that apply: Metoclopramide (Reglan) is contraindicated in patients with: Select 3

A) Extrapyramidal symptoms

B) Parkinsonism

C) Severe allergic reactions

D) Seizure disorders

A

A) Extrapyramidal symptoms
B) Parkinsonism
D) Seizure disorders

and GI obstruction

17
Q

When prescribing Metoclopramide (Reglan) to elderly patients, which of the following is a key precaution?

A) Increased risk of developing hypertension

B) Potential for increased agitation

C) Decreased risk of extrapyramidal symptoms

D) Higher tolerance to side effects

A

B) Potential for increased agitation

18
Q

. Which of the following are common central nervous system (CNS) side effects of Metoclopramide (Reglan)? Select 4

A) Restlessness

B) Drowsiness

C) Insomnia

D) Bradycardia

E) Agitation

A

A) Restlessness,
B) Drowsiness,
C) Insomnia
E) Agitation

19
Q

Which of the following extrapyramidal symptoms can occur as a side effect of Metoclopramide (Reglan)? (Select all that apply)

A) Dystonia

B) Spasms

C) Restless motor function

D) Parkinsonism

A

All of the above

20
Q

True or False: Metoclopramide (Reglan) may cause abdominal cramps, especially when administered rapidly intravenously.

A

Answer: True

21
Q

True or False: Hypotension and HR changes are a known cardiac side effect of Metoclopramide (Reglan).

A

True