Antiemetics - Ondansetron (Zofran) Flashcards
Where is the primary vomiting center located in the brain?
A) Cerebellum
B) Nucleus tractus solitarius (medulla)
C) Thalamus
D) Hypothalamus
B) Nucleus tractus solitarius (medulla)
Which of the following areas provide sensory input to the vomiting center? (Select 3)
A) Chemoreceptor trigger zone
B) Gastrointestinal (GI) tract
C) Vestibular system
D) Prefrontal cortex
A) Chemoreceptor trigger zone,
B) Gastrointestinal (GI) tract,
C) Vestibular system
What is the standard intravenous (IV) dose of Ondansetron for treating nausea and vomiting?
A) 2 mg IV
B) 4 mg IV
C) 8 mg IV
D) 16 mg IV
B) 4 mg IV
TxWes Reference
Dose: 4mg
Onset: 10 min
Duration: 4-9 hr
What is the oral dose range of Ondansetron for treating nausea and vomiting?
A) 2-4 mg PO
B) 4-8 mg PO
C) 8-16 mg PO
D) 16-24 mg PO
C) 8-16 mg PO
For treating pruritus resulting from neuraxial morphine, what is the recommended IV dose of Ondansetron?
A) 2 mg IV
B) 4 mg IV
C) 8 mg IV
D) 16 mg IV
C) 8 mg IV
What is the maximum dose of Ondansetron recommended for patients with liver disease?
A) 4 mg IV
B) 8 mg IV
C) 16 mg IV
D) 24 mg IV
B) 8 mg IV
What is the concentration of Ondansetron solution for intravenous administration?
A) 1 mg/mL
B) 2 mg/mL
C) 4 mg/mL
D) 8 mg/mL
B) 2 mg/mL
What is the primary mechanism of action of Ondansetron (Zofran)?
A) Dopamine receptor antagonist
B) 5-HT3 serotonin receptor antagonist
C) Histamine H1 receptor antagonist
D) GABA receptor agonist
B) 5-HT3 serotonin receptor antagonist
Ondansetron works by blocking serotonin receptors in which of the following locations? (Select 2)
A) Central chemoreceptor trigger zone (CTZ)
B) Peripheral gastrointestinal tract
C) Vestibular system
D) Central nervous system (CNS)
A) Central chemoreceptor trigger zone (CTZ)
B) Peripheral gastrointestinal tract
Which statement accurately describes Ondansetron’s central action?
A) Ondansetron acts centrally by blocking dopamine receptors in the brain.
B) Ondansetron acts centrally at the chemoreceptor trigger zone (CTZ) without causing significant neurological effects.
C) Ondansetron causes notable neurological side effects such as dizziness and confusion.
D) Ondansetron has central effects but primarily targets peripheral serotonin receptors.
B) Ondansetron acts centrally at the chemoreceptor trigger zone (CTZ) without causing significant neurological effects.
What is the primary ligand for Ondansetron (Zofran)?
A) Dopamine
B) Norepinephrine
C) Serotonin
D) Acetylcholine
C) Serotonin
Serotonin’s highest concentration in the body is found in which two primary locations?
A) Liver and Kidneys
B) Brain and Gastrointestinal tract
C) Lungs and Heart
D) Colon and Stomach
B) Brain and Gastrointestinal tract
Which type of nausea is Ondansetron (Zofran) not effective against?
A) Chemotherapy-induced nausea
B) Motion sickness / vestibular stimulation
C) Postoperative nausea
D) Nausea from radiation therapy
B) Motion sickness / vestibular stimulation
Which organs have detectable levels of serotonin, but are not the primary sites of its highest concentration? (Select 3)
A) Liver
B) Kidneys
C) Brain
D) Colon
A) Liver
B) Kidneys
D) Colon
What is the onset time for Ondansetron (Zofran)?
A) Delayed
B) Rapid
C) Slow
D) Variable
Answer: B) Rapid