Antibiotics - Cefoxitin Flashcards
Cefoxitin belongs to which drug class?
A) First generation cephalosporin
B) Second generation cephalosporin
C) Third generation cephalosporin
D) Penicillin
E) Macrolide
B) Second generation cephalosporin
What is the recommended dose range for Cefoxitin in adults and pediatric patients?
A) Adult: 1 gram IV
B) Adult: 2 grams IV
C) Pediatric: 20 mg/kg IV
D) Pediatric: 40 mg/kg IV (max 2 g/dose)
E) Pediatric: 30 mg/kg IV
B) Adult: 2 grams IV
D) Pediatric: 40 mg/kg IV (max 2 g/dose)
Which of the following best describes the mechanism of action (MOA) of Cefoxitin?
A) Disrupts bacterial cell wall synthesis
B) Inhibits bacterial protein synthesis
C) Alters bacterial DNA replication
D) Targets the bacterial cell membrane
E) Disrupts bacterial cell wall synthesis and has extended activity against cephalosporinase
A) Disrupts bacterial cell wall synthesis
E) Disrupts bacterial cell wall synthesis and has extended activity against cephalosporinase
MOA: Gram (-) and (+); Disrupts bacterial cell wall synthesis; extended activity against cephalosporinase produced by gram (-) bacteria
Which of the following statements is true regarding the administration and redosing of Cefoxitin?
A) Cefoxitin should be given 30 minutes before the incision and redosed after 2 hours
B) Cefoxitin should be administered immediately before the incision and not redosed
C) Cefoxitin has a half-life of 2 hours, so redosing is required every hour
D) Cefoxitin can be redosed every 4 hours if needed
E) Cefoxitin’s redosing schedule is flexible and based on patient weight
A) Cefoxitin should be given 30 minutes before the incision and redosed after 2 hours
When to give: give 30 minutes before incision
Redose: Redose after 2 hours (Don’t forget to redose)
What is the half-life of Cefoxitin?
A) 30 minutes
B) 1 hour
C) 2 hours
D) 4 hours
E) 6 hours
B) 1 hour
What percentage of Cefoxitin is metabolized by the liver?
A) 2%
B) 10%
C) 20%
D) 50%
E) 90%
A) 2%
How is Cefoxitin primarily eliminated from the body?
A) Metabolized in the liver and excreted in the urine
B) Metabolized in the liver and excreted in the bile
C) Excreted in the urine
D) Metabolized and excreted via the feces
E) Excreted in breast milk
C) Excreted in the urine
E) Excreted in breast milk
For which types of surgeries is Cefoxitin commonly used? (Select 2)
A) Cardiovascular surgeries
B) Gastrointestinal (GI) surgeries
C) Gynecological (GYN) surgeries
D) Orthopedic surgeries
E) Neurosurgical procedures
B) Gastrointestinal (GI) surgeries
C) Gynecological (GYN) surgeries
What alternative antibiotics should be considered for patients with an IgE-mediated penicillin allergy when Cefoxitin is contraindicated?
A) Vancomycin
B) Clindamycin
C) Azithromycin
D) Ciprofloxacin
E) Metronidazole
A) Vancomycin
B) Clindamycin
Which of the following conditions are contraindications for using Cefoxitin? (Select 2)
A) Steven Johnson Syndrome
B) IgE-mediated penicillin allergy
C) Renal dysfunction
D) Hepatic impairment
E) Diabetes
A) Steven Johnson Syndrome
B) IgE-mediated penicillin allergy
Which of the following statements about Cefoxitin’s pharmacokinetics is accurate? (Select 2)
A) It crosses the placental barrier
B) It is 50% protein-bound
C) It is 75% protein-bound
D) It does not cross the placental barrier
E) It is 100% protein-bound
A) It crosses the placental barrier
C) It is 75% protein-bound
In which situation should Cefoxitin not be continued postoperatively?
A) During a clean procedure
B) During a contaminated procedure
C) When there is significant blood loss
D) If renal function is impaired
E) When surgery lasts more than 24 hours
A) During a clean procedure
When should Cefoxitin be redosed during surgery?
A) After 1 hour
B) If there is a blood loss of 1.5 liters or more
C) After 4 hours
D) Only if there is significant blood loss
E) If the surgery extends beyond 24 hours
B) If there is a blood loss of 1.5 liters or more
What is the maximum duration for administering Cefoxitin during surgery?
A) 1 hour
B) 4 hours
C) 8 hours
D) 24 hours
E) 48 hours
D) 24 hours
