Antibiotics - Clindamycin (Cleocin) Flashcards
What is the drug class of Clindamycin (Cleocin)?
A) Penicillin
B) Lincosamide
C) Cephalosporin
D) Macrolide
E) Aminoglycoside
B) Lincosamide
What is the typical dose range of Clindamycin (Cleocin) for adults when administered IV?
A) 300 mg
B) 600 mg
C) 900 mg
D) 1,200 mg
E) 1,500 mg
C) 900 mg
What is the pediatric dose range for Clindamycin (Cleocin) when administered IV?
A) 5 mg/kg (max 300 mg/dose)
B) 10 mg/kg (max 600 mg/dose)
C) 10 mg/kg (max 900 mg/dose)
D) 15 mg/kg (max 1,200 mg/dose)
E) 20 mg/kg (max 1,500 mg/dose)
C) 10 mg/kg (max 900 mg/dose)
What is the primary mechanism of action of Clindamycin (Cleocin)?
A) Inhibition of nucleic acid synthesis
B) Disruption of bacterial cell wall synthesis
C) Inhibition of protein synthesis via the 50S subunit of the ribosome
D) Inhibition of folic acid synthesis
E) Disruption of bacterial DNA replication
C) Inhibition of protein synthesis via the 50S subunit of the ribosome
When should Clindamycin (Cleocin) be administered in relation to the surgical incision?
A) Immediately after incision
B) 30 minutes before incision
C) 1 hour before incision
D) 2 hours before incision
E) Post-operatively
Correct Answer
B) 30 minutes before incision
What is the recommended redosing interval for Clindamycin (Cleocin) if the procedure extends beyond 6 hours?
A) Every 2 hours
B) Every 4 hours
C) Every 6 hours
D) Every 8 hours
E) No redosing required
C) Every 6 hours
Redose: Redose after 6 hours; unless single dose
What is the typical half-life of Clindamycin (Cleocin)?
A) 1-2 hours
B) 2-4 hours
C) 4-6 hours
D) 6-8 hours
E) 8-10 hours
B) 2-4 hours
How is Clindamycin (Cleocin) primarily metabolized in the body?
A) By the liver enzymes CYP (cytochrome P450)
B) By the kidneys
C) By the gastrointestinal tract
D) By plasma esterases
E) By hepatic conjugation
A) By the liver enzymes CYP (cytochrome P450)
What is the primary route of elimination for Clindamycin (Cleocin)?
A) Via inactive metabolites in the urine
B) Via unchanged drug in the feces
C) Via biliary excretion of inactive metabolites
D) Via active renal secretion
E) Via direct elimination through the lungs
C) Via biliary excretion of inactive metabolites
When is Clindamycin (Cleocin) typically used as an alternative regimen?
A) When the patient has an allergy to penicillin and Cefazolin cannot be used
B) When treating viral infections
C) When the patient is undergoing routine dental procedures
D) As the primary antibiotic for gram-negative infections
E) When the patient has no known drug allergies
A) When the patient has an allergy to penicillin and Cefazolin cannot be used
In which scenario is Clindamycin (Cleocin) commonly used in conjunction with Gentamicin?
A) In the treatment of respiratory infections
B) For prophylaxis in C-sections
C) For treating urinary tract infections
D) For managing acute gastroenteritis
E) As a single-agent therapy for wound infections
B) For prophylaxis in C-sections
Which of the following combinations is typically used with Clindamycin (Cleocin) for prophylaxis in surgical procedures?
A) Penicillin
B) Gentamicin
C) Vancomycin
D) Erythromycin
E) Tetracycline
B) Gentamicin
Usually in conjunction with aminoglycoside Abx (gentamicin);
What is a primary contraindication for using Clindamycin (Cleocin)?
A) Hypersensitivity to Clindamycin
B) History of kidney disease
C) Hypertension
D) Diabetes Mellitus
E) Asthma
A) Hypersensitivity to Clindamycin
What precaution should be taken if the surgical procedure is classified as clean when using Clindamycin (Cleocin)?
A) Administer antibiotics post-operatively
B) Don’t give antibiotics post-operatively
C) Continue antibiotics for 48 hours post-operatively
D) Redose antibiotics every 6 hours post-operatively
E) Increase dosage if clean procedure
B) Don’t give antibiotics post-operatively
When should Clindamycin (Cleocin) be redosed during a surgical procedure?
A) After 1 liter of blood loss
B) After 1.5 liters of blood loss
C) After 2 liters of blood loss
D) Only if blood loss exceeds 3 liters
E) Do not redose based on blood loss
B) After 1.5 liters of blood loss
