Antibiotics - Cefazolin (Ancef) Flashcards
Which of the following statements accurately describe the drug class of Cefazolin (Ancef)?
A) Second-generation cephalosporin
B) First-generation cephalosporin
C) Third-generation cephalosporin
D) Beta-lactam antibiotic
E) Macrolide antibiotic
B) First-generation cephalosporin
D) Beta-lactam antibiotic
What are the recommended dosing ranges for Cefazolin (Ancef) in adults and pediatric patients?
A) Adult: 1 gram IV;
Pediatric: 20 mg/kg IV (max 2g/dose)
B) Adult: 2 grams IV; 3 grams if >120 kg;
Pediatric: 30 mg/kg IV (max 3g/dose)
C) Adult: 1 gram IV;
Pediatric: 30 mg/kg IV (max 3g/dose)
D) Adult: 3 grams IV;
Pediatric: 30 mg/kg IV (max 2g/dose)
E) Adult: 2 grams IV;
Pediatric: 20 mg/kg IV (max 2g/dose)
B) Adult: 2 grams IV; 3 grams if >120 kg;
Pediatric: 30 mg/kg IV (max 3g/dose)
What is the mechanism of action (MOA) of Cefazolin (Ancef)?
A) Disrupts bacterial cell wall synthesis
B) Inhibits bacterial protein synthesis
C) Disrupts bacterial cell membrane function
D) Inhibits bacterial nucleic acid synthesis
E) Inhibits bacterial folic acid synthesis
A) Disrupts bacterial cell wall synthesis
MOA: Gram (-) and (+); Disrupts bacterial cell wall synthesis
When should Cefazolin (Ancef) be administered in relation to a surgical incision?
A) 30 minutes before the incision
B) 1 hour before the incision
C) Immediately after the incision
D) 2 hours before the incision
E) 1 hour after the incision
A) 30 minutes before the incision
Under what conditions should Cefazolin (Ancef) be redosed?
A) Redose every 2 hours during prolonged procedures
B) Redose after 4 hours if multiple doses are required
C) Redose after 4 hours, unless only a single dose was administered
D) Redose immediately after the initial dose wears off
E) Redose every 6 hours regardless of the procedure duration
C) Redose after 4 hours, unless only a single dose was administered
What is the half life of Cefazolin?
A) 1 hr
B) 2 hr
C) 4 hr
D) 5 hr
B) 2 hr
How is Cefazolin (Ancef) primarily eliminated from the body?
A) Metabolized by the liver and excreted in bile
B) Metabolized and then excreted in urine
C) Eliminated unchanged primarily by the kidneys
D) Metabolized in the kidneys and excreted in urine
C) Eliminated unchanged primarily by the kidneys
Elimination: Not metabolized and primarily eliminated unchanged by the kidneys
Cefazolin (Ancef) is used for prophylaxis in which of the following scenarios?
A) Clean procedures before incision
B) High-risk procedures post-incision
C) Emergency procedures
D) Chronic infection management
E) Procedures with a high risk of contamination
A) Clean procedures before incision
In which types of surgical procedures is Cefazolin (Ancef) commonly used for prophylaxis?
A) ENT (ear, nose, and throat)
B) Neuro (neurological)
C) Gynecologic
D) Breast
E) Plastics
F) All of the above
F) All of the above
Which of the following is true regarding Cefazolin (Ancef) and allergic reactions?
A) Cefazolin can be administered if a patient has a non-IgE mediated allergic reaction
B) Cefazolin should be avoided in cases of any allergic reaction
C) Cefazolin is used in 90% of prophylactic cases
D) Cefazolin is given only if there is an IgE-mediated allergic reaction
E) Cefazolin is ineffective in patients with allergic reactions
A) Cefazolin can be administered if a patient has a non-IgE mediated allergic reaction
C) Cefazolin is used in 90% of prophylactic cases
Which of the following conditions is a contraindication for administering Cefazolin (Ancef)?
A) Stephen Johnson Syndrome
B) Non-IgE mediated PCN allergy
C) IgE mediated PCN allergy
D) Asthma
E) Hypertension
A) Stephen Johnson Syndrome
C) IgE mediated PCN allergy
C/I: Stephen Johnson Syndrome, PCN allergy (if IgE mediated) so give vanco or clindamycin instead
What should be administered instead of Cefazolin (Ancef) if a patient has an IgE mediated allergy to penicillin?
A) Vancomycin
B) Clindamycin
C) Ciprofloxacin
D) Metronidazole
E) Gentamicin
A) Vancomycin
B) Clindamycin
Which of the following precautions are associated with the use of Cefazolin (Ancef) in clean procedures?
A) Antibiotics should be continued post-operatively
B) Redose if there is a blood loss of 1.5 liters or more
C) Cefazolin should not be continued past 24 hours of surgery
D) Prolonged effect may occur with renal dysfunction
E) Cefazolin can be used as a long-term prophylactic measure
B) Redose if there is a blood loss of 1.5 liters or more
C) Cefazolin should not be continued past 24 hours of surgery
D) Prolonged effect may occur with renal dysfunction
Precautions: If clean procedure, no Abx post op
Which of the following are common side effects of Cefazolin (Ancef)?
A) Allergic reaction
B) Thrombophlebitis
C) Diarrhea
D) Hypertension
E) Insomnia
A) Allergic reaction
B) Thrombophlebitis
C) Diarrhea
