Vasculitis

Question 1

Def = Granulomatosis vasculitis involving branches of the carotid a.

Answer 1

Temporal/Giant cell arteritis

Question 2

Bx = segmental intimal fibrosis w/ giant cells

Answer 2

Temporal/Giant cell arteritis

Question 3

Def = Granulomatous vasculitis of aortic arch at branch points

Answer 3

Takayasu arteritis

Question 4

MC demographic for Takayasu arteritis

Answer 4

Asian W < 50

Question 5

Sx’s = Weak/absent UE pulses

Answer 5

Takayasu arteritis

Question 6

Which lab value will be elevated in Takayasu arteritis

Answer 6

ESR

Question 7

Def = Necrotizing vasculitis of many organs, SPARING lungs

Answer 7

PAN

Question 8

MC demographic for PAN

Answer 8

Young adults w/ HTN

Question 9

Bx = transmural inflammation w/ fibrinoid necrosis

Answer 9

PAN

Question 10

What is seen on imaging in PAN

Answer 10

‘string-of-beads’

Question 11

PAN assc w/…

Answer 11

HBV

Question 12

Sx’s = erythematous rash on palms/soles w/ enlarged cervical LN’s in Asian child < 5 yo

Answer 12

Kawasaki disease

Question 13

Tx of Kawasaki disease =

Answer 13

ASA, IVIg

Question 14

Def = Necrotizing vasculitis involving digits in young, heavy smokers

Answer 14

Buerger disease

Question 15

Def = Necrotizing granulomatous vasculitis of nasopharynx, lungs, and kidneys

Answer 15

Wegener Granulomatosis

Question 16

Bx = large necrotizing granulomas w/ adjacent necrotizing vasculitis

Answer 16

Wegener Granulomatosis

Question 17

c-ANCA +

Answer 17

Wegener Granulomatosis

Question 18

Sx’s = sinusitis, nasopharyngeal ulceration, hemoptysis (b/l lung infiltrates), hematuria in middle-aged male

Answer 18

Wegener Granulomatosis

Question 19

Pneumonic for Wegener’s Granulomatosis

Answer 19

weCner –> c-ANCA, Cyclophosphamide, C-shaped organ involvement

Question 20

Def = Necrotizing vasculitis of lungs and kidneys

Answer 20

Microscopic Polyangiitis

Question 21

p-ANCA +

Answer 21

Microscopic Polyangiitis, Churg-Straus syndrome

Question 22

Tx of Microscopic Polyangiitis

Answer 22

Cyclophosphamide

Question 23

Def = Necrotizing granulomatous inflammation w/ eosinophilia involving lungs and heart

Answer 23

Churg-Strauss syndrome

Question 24

Def = IgA immune complex deposition in kidneys following URI in kids

Answer 24

Henoch-Schonlein purpura

Question 25

Sx’s = palpable purpura on buttocks and legs, GI pain/bleeding, hematuria following URI

Answer 25

Henoch-Schonlein purpura

Question 26

Tx of Henoch-Schonlein purpura

Answer 26

Self-limited