ABX - MOA

Question 1

MOA of Penicillins

Answer 1

Bock PBP cross-linking of peptidoglycan cell wall

Question 2

MOA of Penicillinase-Sensitive Penicillins

Answer 2

Block PBP cross-linking of peptidoglycan cell w/ resistance against ß-lactamase

Question 3

MOA of Penicillinase-Resistant Penicillins

Answer 3

Block PBP cross-linking of peptidoglycan cell wall w/ resistance against Penicilinase

Question 4

MOA of ß-lactamase inhibitors

Answer 4

Inhibit ß-lactamase enzyme –> inhibition of Penicillin breakdown

Question 5

MOA of Cephalosporins

Answer 5

Inhibit cell wall synthesis but less susceptible to Penicillinases

Question 6

MOA of Carbapenems

Answer 6

ß–lactamase resistant broad-spectrum ABX

Question 7

MOA of Aztreonam

Answer 7

Binds PBP-3 inhibiting peptidoglycan cross-linking

Question 8

MOA of Vancomycin

Answer 8

Binds D-Ala-D-Ala on cell wall inhibiting peptidoglycan formation

Question 9

MOA of Aminoglycosides

Answer 9

Inhibit 30S ribosome subunit

Question 10

MOA of Tetracyclines

Answer 10

Prevent attachment of aminoacyl-tRNA to 30S ribosome subunit

Question 11

MOA of Clindamycin

Answer 11

Blocks peptide transfer at 50S ribosome subunit

Question 12

MOA of Linezolid

Answer 12

Prevents formation of initiation complex by binding 50S ribosome subunit

Question 13

MOA of Macrolides

Answer 13

Inhibit protein synthesis by binding 50S ribosome subunit

Question 14

MOA of SMX

Answer 14

Inhibits Dihydropteroate synthase –> inhibition of folate synthesis

Question 15

MOA of Trimethoprim (TMP)

Answer 15

Inhibits bacterial Dihydrofolate reductase

Question 16

MOA of Fluoroquinolones

Answer 16

Inhibit prokaryotic Topoisomerase II (DNA gyrase)

Question 17

MOA of Metronidazole

Answer 17

Forms free radical metabolites –> cell damage

Question 18

SE of Ethambutol

Answer 18

Optic neuropathy

Question 19

SE of Isoniazid

Answer 19

Drug-induced SLE, Hepatotoxicity

Question 20

SE of Rifampin/Rifabutin

Answer 20

Orange body fluids