Anti-Fungal Drugs Flashcards
1
Q
MOA of Amphotericin B
A
Binds ergosterol –> membrane pores
2
Q
MOA of Flucytosine
A
Inhibits DNA/RNA synthesis by conversion to 5-FU
3
Q
MOA of Azoles
A
Inhibit fungal serol (ergosterol) synthesis
4
Q
MOA of Echinocandins
A
Inhibit ß-glucan –> inhibition of cell wall synthesis
5
Q
Echinocandin drugs =
A
‘fungins’
6
Q
MOA of Griseofulvin
A
Disrupts mitosis via microtubule dysfunction
7
Q
MOA of Chloroquine
A
Blocks detoxification of Heme into Hemozoin –> toxicity
8
Q
SE of Amphotericin B
A
HoTN, IV phlebitis
9
Q
SE of Flucytosine
A
BM suppression
10
Q
SE of Azoles
A
T synthesis inhibition
11
Q
SE of Eichonocandins
A
GI upset, Flushing
