Pharmacokinetics/Pharmacodynamics Flashcards
1st order velocity =
Rxn velocity is directly proportional to the concentration of the substrate
0 order velocity =
Rxn velocity is the same no matter the concentration of the substrate
What is Km
Concentration of a substrate at 1/2 Vmax
How does a competitive inhibitor work
Binds to substrate binding site to prevent substrate binding but addition of higher amounts of substrate can overcome the inhibitor
How does a non-competitive inhibitor work
Binds to an allosteric binding site to prevent activation of the enzyme-substrate complex
What does a competitive inhibitor do to the Km and Vmax
Km increased, Vmax, no ∆
What does a non-competitive inhibitor do to the Km and Vmax
Km no ∆, Vmax decreased
How does a competitive antagonist affect the potency of an agonist
Decreases potency
How does a non-competitive agonist affect the efficacy of an agonist
Decreases efficacy
How does a partial agonist affect efficacy and potency
Efficacy is ALWAYS decreased; Potency may be increased/decreased
Which drug inhibits EtOH dehydrogenase
Fomepizole
What drug inhibits Acetaldehyde Dehydrogenase
Disulfiram
What is 1st order elimination
Constant proportion of drug eliminated per unit time
What is 0 order elimination
Constant amount of drug eliminated per unit time
