Repro - Endometrium/Myometrium Flashcards
Def = malignant proliferation of myometrial SM
Leiomyosarcoma
What is Adenomyosis
Endometriosis that involves the uterine myometrium
What is the most important predictor of progression to cancer in endometrial hyperplasia
Presence of cellular atypia
Gross = multiple, well-defined, white, whorled masses that distort the uterus
Leiomyoma (Fibroid)
Leiomyoma (fibroid) is MC d/t…
E exposure
What causes shedding of the endometrium
Loss of progesterone
How is chronic endometritis characterized
Lymphocytes and plasma cells present in the endometrium
Demographic for Leiomyosarcoma
Post-menopausal women
MC site of endometriosis
Ovary –> ‘Chocolate cyst”
How does an anovulatory cycle affect E and Prog
Results in E-driven proliferation w/out Prog-driven secretory state
Bx = serous w/ papillary structures w/ psammoma bodies
Sporadic type Endometrial carcinoma
Def = benign proliferation of myometrial SM
Leiomyoma (Fibroid)
Sx’s of endometrial hyperplasia
Post-menopausal bleeding
What drug can cause endometrial polyps
Tamoxifen
Gross = single lesion w/ areas of necrosis and hemorrhage
Leiomyosarcoma
