Heme/Onc Drugs

Question 1

MOA of 6-Mercaptopurine

Answer 1

Purine analogs decreasing purine synthesis

Question 2

MOA of Cytarabine

Answer 2

Pyrimidine analog –> DNA chain termination

Question 3

MOA of 5-Fluorocuracil

Answer 3

Pyrimidine analog –> Inhibition of Thymidylate synthase

Question 4

MOA of Methotrexate

Answer 4

Folic acid analog –> inhibition of DHF-reductase

Question 5

MOA of Bleomycin

Answer 5

Induces free radial formation –> DNA strand breaks

Question 6

MOA of Doxorubicin

Answer 6

Interferes w/ Topoisomerase II

Question 7

MOA of Cyclophosphamide

Answer 7

Cross-links DNA

Question 8

MOA of Paclitaxel

Answer 8

Hyperstabilizes microtubule

Question 9

MOA of ‘-taxanes’

Answer 9

Hyperstabilizes microtubules

Question 10

MOA of Vincristine

Answer 10

Binds ß-tubulin and inhibits microtubule polymerization

Question 11

MOA of Vinblastine

Answer 11

Binds ß-tubulin and inhibits microtubule polymerization

Question 12

MOA of Cisplatin

Answer 12

Cross-links DNA

Question 13

MOA of Etoposide, Teniposide

Answer 13

Inhibits Topo2 –> increased DNA degradation

Question 14

MOA of Topotecan, Irinotecan

Answer 14

Inhibits Topo1 –> inhibition of DNA unwinding

Question 15

MOA of Imatinib

Answer 15

Tyrosine kinase inhibitor of BCR-ABL and c-KIT

Question 16

MOA of Rituximab

Answer 16

MAb against CD20 on most B-cell neoplasms

Question 17

MOA of Tamoxifen, Raloxifen

Answer 17

SERM antagonist in breast and agonist in bone/endometrium

Question 18

MOA of Trastuzumab (Herceptin)

Answer 18

MAb against HER2

Question 19

SE of Cytarabine

Answer 19

Pancytopenia w/ megaloblastic anemia

Question 20

SE of 5-FU

Answer 20

Hand-foot syndrome

Question 21

SE of Doxorubicin

Answer 21

Alopecia

Question 22

SE of Cyclophosphamide

Answer 22

SIADH, Hemorrhagic cystitis

Question 23

SE of Bleomycin

Answer 23

Pulmonary fibrosis, Skin hyperpigmentation

Question 24

SE of Paclitaxel

Answer 24

Neuropathy

Question 25

SE of Cisplatin/Carboplatin

Answer 25

Ototoxicity, Peripheral neuropathy

Question 26

SE of Rituximab

Answer 26

Increased risk of PML

Question 27

SE of Trastuzumab (Herceptin)

Answer 27

Cardiotoxicity

Question 28

SE of Vincristine

Answer 28

Peripheral neuropathy

Question 29

Thrombolytic drugs =

Answer 29

Alteplase (tPA), Streptokinase

Question 30

Direct thrombin inhibitor drugs =

Answer 30

Argatroban, Dabigatran

Question 31

ADP-R inhibitor drugs =

Answer 31

Clopidogrel, Prasugrel, Ticagrelor, Ticlopidine

Question 32

PDE inhibitor drugs =

Answer 32

Cilostazol, Dipyridamole

Question 33

GP2b/3a inhibitor drugs =

Answer 33

Abciximab, Tirofiban