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Zak, Level 1 > Heme/Onc Drugs > Flashcards

Heme/Onc Drugs Flashcards

1
Q

MOA of 6-Mercaptopurine

A

Purine analogs decreasing purine synthesis

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2
Q

MOA of Cytarabine

A

Pyrimidine analog –> DNA chain termination

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3
Q

MOA of 5-Fluorocuracil

A

Pyrimidine analog –> Inhibition of Thymidylate synthase

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4
Q

MOA of Methotrexate

A

Folic acid analog –> inhibition of DHF-reductase

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5
Q

MOA of Bleomycin

A

Induces free radial formation –> DNA strand breaks

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6
Q

MOA of Doxorubicin

A

Interferes w/ Topoisomerase II

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7
Q

MOA of Cyclophosphamide

A

Cross-links DNA

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8
Q

MOA of Paclitaxel

A

Hyperstabilizes microtubule

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9
Q

MOA of ‘-taxanes’

A

Hyperstabilizes microtubules

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10
Q

MOA of Vincristine

A

Binds ß-tubulin and inhibits microtubule polymerization

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11
Q

MOA of Vinblastine

A

Binds ß-tubulin and inhibits microtubule polymerization

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12
Q

MOA of Cisplatin

A

Cross-links DNA

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13
Q

MOA of Etoposide, Teniposide

A

Inhibits Topo2 –> increased DNA degradation

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14
Q

MOA of Topotecan, Irinotecan

A

Inhibits Topo1 –> inhibition of DNA unwinding

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15
Q

MOA of Imatinib

A

Tyrosine kinase inhibitor of BCR-ABL and c-KIT

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16
Q

MOA of Rituximab

A

MAb against CD20 on most B-cell neoplasms

17
Q

MOA of Tamoxifen, Raloxifen

A

SERM antagonist in breast and agonist in bone/endometrium

18
Q

MOA of Trastuzumab (Herceptin)

A

MAb against HER2

19
Q

SE of Cytarabine

A

Pancytopenia w/ megaloblastic anemia

20
Q

SE of 5-FU

A

Hand-foot syndrome

21
Q

SE of Doxorubicin

A

Alopecia

22
Q

SE of Cyclophosphamide

A

SIADH, Hemorrhagic cystitis

23
Q

SE of Bleomycin

A

Pulmonary fibrosis, Skin hyperpigmentation

24
Q

SE of Paclitaxel

A

Neuropathy

25
Q

SE of Cisplatin/Carboplatin

A

Ototoxicity, Peripheral neuropathy

26
Q

SE of Rituximab

A

Increased risk of PML

27
Q

SE of Trastuzumab (Herceptin)

A

Cardiotoxicity

28
Q

SE of Vincristine

A

Peripheral neuropathy

29
Q

Thrombolytic drugs =

A

Alteplase (tPA), Streptokinase

30
Q

Direct thrombin inhibitor drugs =

A

Argatroban, Dabigatran

31
Q

ADP-R inhibitor drugs =

A

Clopidogrel, Prasugrel, Ticagrelor, Ticlopidine

32
Q

PDE inhibitor drugs =

A

Cilostazol, Dipyridamole

33
Q

GP2b/3a inhibitor drugs =

A

Abciximab, Tirofiban

Zak, Level 1 (41 decks)

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