Tumor suppressor genes, tumor markers Flashcards
Rb (2)
Retinoblastoma
Osteosarcoma
BRCA1 (2)
Breast cancer
Ovarian cancer
BRCA2
Breast cancer
p53
Most human cancers, Li-Fraumeni syndrome
p16
Melanoma
APC
Colorectal cancer
WT1
Wilm’s tumor
NF1
Neurofibromatosis type 1
NF2
Neurofibromatosis type 2
DPC
Pancreatic cancer
DCC
Colon cancer
PSA
Prostate problems
Prostatic acid phosphatase
Prostate carcinoma
CEA
carcinoembryonic antigen (colorectal and pancreatic, also gastric and breast)
alpha-fetoprotein (2)
Hepatocellular carcinoma
Nonseminomatous germ cell tumors of the testis (yolk sac tumor)
beta-hCG (3)
Hydatidiform moles
Choriocarcinoma
Gestational trophoblastic tumors
CA-125 (2)
Ovarian, malignant epithelial tumors (any peritoneal irritation: bad for screening)
S-100 (3)
Melanoma
Neural tumors
Astrocytomas
Alkaline phosphatase (3)
Metastases to bone
Obstructive biliary disease
Paget’s disease of bone
Bombesin (3)
Neuroblastoma
Lung
Gastric
TRAP
Tartrate-resistant acid phosphatase; hairy cell leukemia
CA-19-9
Pancreatic adenocarcinoma