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Step 1 stuff > Tumor suppressor genes, tumor markers > Flashcards

Tumor suppressor genes, tumor markers Flashcards

1
Q

Rb (2)

A

Retinoblastoma

Osteosarcoma

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2
Q

BRCA1 (2)

A

Breast cancer

Ovarian cancer

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3
Q

BRCA2

A

Breast cancer

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4
Q

p53

A

Most human cancers, Li-Fraumeni syndrome

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5
Q

p16

A

Melanoma

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6
Q

APC

A

Colorectal cancer

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7
Q

WT1

A

Wilm’s tumor

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8
Q

NF1

A

Neurofibromatosis type 1

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9
Q

NF2

A

Neurofibromatosis type 2

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10
Q

DPC

A

Pancreatic cancer

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11
Q

DCC

A

Colon cancer

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12
Q

PSA

A

Prostate problems

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13
Q

Prostatic acid phosphatase

A

Prostate carcinoma

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14
Q

CEA

A

carcinoembryonic antigen (colorectal and pancreatic, also gastric and breast)

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15
Q

alpha-fetoprotein (2)

A

Hepatocellular carcinoma

Nonseminomatous germ cell tumors of the testis (yolk sac tumor)

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16
Q

beta-hCG (3)

A

Hydatidiform moles
Choriocarcinoma
Gestational trophoblastic tumors

17
Q

CA-125 (2)

A

Ovarian, malignant epithelial tumors (any peritoneal irritation: bad for screening)

18
Q

S-100 (3)

A

Melanoma
Neural tumors
Astrocytomas

19
Q

Alkaline phosphatase (3)

A

Metastases to bone
Obstructive biliary disease
Paget’s disease of bone

20
Q

Bombesin (3)

A

Neuroblastoma
Lung
Gastric

21
Q

TRAP

A

Tartrate-resistant acid phosphatase; hairy cell leukemia

22
Q

CA-19-9

A

Pancreatic adenocarcinoma

Step 1 stuff (36 decks)

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