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Step 1 stuff > Bacterial Toxins > Flashcards

Bacterial Toxins Flashcards

1
Q

TSST-1: organism

A

S. aureus

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2
Q

TSST-1: toxin type

A

superantigen

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3
Q

TSST-1: effects

A

toxic shock syndrome: fever, rash, shock

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4
Q

Scarlet fever-erythrogenic toxin: organism

A

S. pyogenes

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5
Q

Scarlet fever-erythrogenic toxin: effects

A

toxic shock-like syndrome

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6
Q

Scarlet fever-erythrogenic toxin: toxin type

A

superantigen

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7
Q

C. diptheria toxin: mechanism

A

ADP ribosylating A-B toxin: inactivates EF-2

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8
Q

C. diptheria toxin: effects

A

pharyngitis, pseudomembrane in throat

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9
Q

V. cholerae toxin: mechanism

A

ADP ribosylating A-B toxin: ribosylation of G protein upregulates adenylyl cyclase

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10
Q

V. cholerae toxin: effects

A

H2O moves out of cell: rice-water diarrhea

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11
Q

E. coli heat labile toxin: mechanism

A

ADP ribosylating A-B toxin: stimulates adenylate cyclase

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12
Q

E. coli heat labile toxin: effect

A

rice-water diarrhea

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13
Q

E. coli heat stable toxin: mechanism

A

ADP ribosylating A-B toxin simlates guanylate cyclase

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14
Q

E. coli heat stable toxin: effect

A

Rice water diarrhea

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15
Q

B. pertussis toxin: mechanism

A

ADP ribosylating A-B toxin: inhibits Galpha1, increases cAMP

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16
Q

B. pertussis toxin: effects

A

Whooping cough

lymphocytosis

17
Q

alpha toxin: organism

A

C. perfringins

18
Q

alpha toxin: effect

A

gas gangrene

19
Q

C. tetani toxin: mechanism

A

blocks release of GABA and glycine

20
Q

C. tetani toxin: effect

21
Q

C. botulinum toxin: mechanism

A

blocks release of Ach

22
Q

C. botulinum toxin: effect

A

anticholinergic symptoms, flaccid paralysis

23
Q

Edema factor: organism

A

B. anthracis

24
Q

Edema factor: mechanism

A

adenylate cyclase

25
Q

Shiga toxin: mechanism

A

cleaves host rRNA, inactivates 60S ribosome, enhances cytokine release

26
Q

Shiga toxin: effect

27
Q

Streptolysin O: organism

A

S. pyogenes

28
Q

Streptolysin O: mechanism

29
Q

Streptolysin S: organism

A

S. pyogenes

30
Q

Streptolysin S: mechanism

31
Q

Erythrogenic/pyrogenic toxins: organism

A

S. Pyogenes

32
Q

Erythrogenic/pyrogenic toxins: effect

A

skin rash and fever of scarlet fever

33
Q

alpha toxin of S. aureus: effect

34
Q

beta toxin of S. aureus: effect

A

sphingomyelinase

35
Q

proteins A, B, and C of gamma-toxin of S. aureus: effects

A

A and B: hemolysin

B and C: leukocidin

36
Q

hemolysin of S. aureus: effect

37
Q

leukocidin of S. aureus: effect

A

destroys leukocytes

38
Q

enterotoxins A-E of S. aureus: effect

A

food poisoning, vomiting and diarrhea

39
Q

epidermolytic/exfoliative toxin of S. aureus: effect

A

epithelial cell lysis, scalded skin syndrome

Step 1 stuff (36 decks)

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