Bacterial Toxins Flashcards

1
Q

TSST-1: organism

A

S. aureus

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2
Q

TSST-1: toxin type

A

superantigen

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3
Q

TSST-1: effects

A

toxic shock syndrome: fever, rash, shock

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4
Q

Scarlet fever-erythrogenic toxin: organism

A

S. pyogenes

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5
Q

Scarlet fever-erythrogenic toxin: effects

A

toxic shock-like syndrome

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6
Q

Scarlet fever-erythrogenic toxin: toxin type

A

superantigen

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7
Q

C. diptheria toxin: mechanism

A

ADP ribosylating A-B toxin: inactivates EF-2

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8
Q

C. diptheria toxin: effects

A

pharyngitis, pseudomembrane in throat

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9
Q

V. cholerae toxin: mechanism

A

ADP ribosylating A-B toxin: ribosylation of G protein upregulates adenylyl cyclase

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10
Q

V. cholerae toxin: effects

A

H2O moves out of cell: rice-water diarrhea

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11
Q

E. coli heat labile toxin: mechanism

A

ADP ribosylating A-B toxin: stimulates adenylate cyclase

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12
Q

E. coli heat labile toxin: effect

A

rice-water diarrhea

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13
Q

E. coli heat stable toxin: mechanism

A

ADP ribosylating A-B toxin simlates guanylate cyclase

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14
Q

E. coli heat stable toxin: effect

A

Rice water diarrhea

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15
Q

B. pertussis toxin: mechanism

A

ADP ribosylating A-B toxin: inhibits Galpha1, increases cAMP

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16
Q

B. pertussis toxin: effects

A

Whooping cough

lymphocytosis

17
Q

alpha toxin: organism

A

C. perfringins

18
Q

alpha toxin: effect

A

gas gangrene

19
Q

C. tetani toxin: mechanism

A

blocks release of GABA and glycine

20
Q

C. tetani toxin: effect

21
Q

C. botulinum toxin: mechanism

A

blocks release of Ach

22
Q

C. botulinum toxin: effect

A

anticholinergic symptoms, flaccid paralysis

23
Q

Edema factor: organism

A

B. anthracis

24
Q

Edema factor: mechanism

A

adenylate cyclase

25
Shiga toxin: mechanism
cleaves host rRNA, inactivates 60S ribosome, enhances cytokine release
26
Shiga toxin: effect
HUS
27
Streptolysin O: organism
S. pyogenes
28
Streptolysin O: mechanism
hemolysin
29
Streptolysin S: organism
S. pyogenes
30
Streptolysin S: mechanism
hemolysis
31
Erythrogenic/pyrogenic toxins: organism
S. Pyogenes
32
Erythrogenic/pyrogenic toxins: effect
skin rash and fever of scarlet fever
33
alpha toxin of S. aureus: effect
hemolysis
34
beta toxin of S. aureus: effect
sphingomyelinase
35
proteins A, B, and C of gamma-toxin of S. aureus: effects
A and B: hemolysin | B and C: leukocidin
36
hemolysin of S. aureus: effect
hemolysis
37
leukocidin of S. aureus: effect
destroys leukocytes
38
enterotoxins A-E of S. aureus: effect
food poisoning, vomiting and diarrhea
39
epidermolytic/exfoliative toxin of S. aureus: effect
epithelial cell lysis, scalded skin syndrome