Cytokines, Cell surface proteins Flashcards
Il-1 secreted by
macrophages
Il-1: 4 actions
acute inflammation
chemokine production to recruit leukocytes
activates endothelium to express adhesion molecules
endogenous pyrogen
Il-2 secreted by
Th1 cells
Il-2 action
Stimulates growth of helper and cytotoxic T cells
Il-3 secreted by
activated T cells
Il-3 action
Supports growth and differentiation of bone marrow stem cells
Il-4 secreted by
Th2 cells
Il-4 2 actions
Growth of B cells
Class switching to IgE and IgG
Il-5 secreted by
Th2 cells
Il-5 3 actions
Differentiation of B cells
Class switching to IgA
Production/activation of Eosinophils
Il-6 secreted by (2)
Th cells and macrophages
Il-6 2 actions
Production of acute-phase reactants
Production of immunoglobulins
Il-8 secreted by
macrophages
Il-8 action
Chemotaxis for neutrophils
Il-10 secreted by
regulatory T cells
Il-10 2 actions
inhibits activated T cells.
Activates Th2, inhibits Th1
Il-12 secreted by (2)
B cells and macrophages
IL-12 2 actions
Activates NK cells
Activates Th1 cells
gamma-interferon secreted by
Th1 cells
gamma-interferon 3 actions
stimulates macrophages
stimulates th1
inhibits th2
TNF secreted by
macrophages
TNF 2 actions
mediates septic shock
leukocyte recruitment
Th cells: 5 cell markers
CD4 TCR CD3 CD28 CD40L
Tc cells: 3 cell markers
CD8
TCR
CD3
B cells: 7 cell markers
IgD IgM CD19 CD20 CD21 CD40 MHC II B7
Macrophages: 7 markers
MHC II B7 CD 14 CD 40 Fc receptor C3b receptor CD 16
NK cells: 3 markers
Receptors for MHC I
CD16
CD56
Markers found on all WBCs, RBCs, platelets (2)
CD55
CD59
