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Step 1 stuff > Cytokines, Cell surface proteins > Flashcards

Cytokines, Cell surface proteins Flashcards

1
Q

Il-1 secreted by

A

macrophages

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2
Q

Il-1: 4 actions

A

acute inflammation
chemokine production to recruit leukocytes
activates endothelium to express adhesion molecules
endogenous pyrogen

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3
Q

Il-2 secreted by

A

Th1 cells

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4
Q

Il-2 action

A

Stimulates growth of helper and cytotoxic T cells

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5
Q

Il-3 secreted by

A

activated T cells

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6
Q

Il-3 action

A

Supports growth and differentiation of bone marrow stem cells

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7
Q

Il-4 secreted by

A

Th2 cells

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8
Q

Il-4 2 actions

A

Growth of B cells

Class switching to IgE and IgG

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9
Q

Il-5 secreted by

A

Th2 cells

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10
Q

Il-5 3 actions

A

Differentiation of B cells
Class switching to IgA
Production/activation of Eosinophils

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11
Q

Il-6 secreted by (2)

A

Th cells and macrophages

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12
Q

Il-6 2 actions

A

Production of acute-phase reactants

Production of immunoglobulins

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13
Q

Il-8 secreted by

A

macrophages

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14
Q

Il-8 action

A

Chemotaxis for neutrophils

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15
Q

Il-10 secreted by

A

regulatory T cells

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16
Q

Il-10 2 actions

A

inhibits activated T cells.

Activates Th2, inhibits Th1

17
Q

Il-12 secreted by (2)

A

B cells and macrophages

18
Q

IL-12 2 actions

A

Activates NK cells

Activates Th1 cells

19
Q

gamma-interferon secreted by

A

Th1 cells

20
Q

gamma-interferon 3 actions

A

stimulates macrophages
stimulates th1
inhibits th2

21
Q

TNF secreted by

A

macrophages

22
Q

TNF 2 actions

A

mediates septic shock

leukocyte recruitment

23
Q

Th cells: 5 cell markers

A 
CD4
TCR
CD3
CD28
CD40L
24
Q

Tc cells: 3 cell markers

A

CD8
TCR
CD3

25
Q

B cells: 7 cell markers

A 
IgD
IgM
CD19
CD20
CD21
CD40
MHC II
B7
26
Q

Macrophages: 7 markers

A 
MHC II
B7
CD 14
CD 40
Fc receptor
C3b receptor
CD 16
27
Q

NK cells: 3 markers

A

Receptors for MHC I
CD16
CD56

28
Q

Markers found on all WBCs, RBCs, platelets (2)

A

CD55

CD59

Step 1 stuff (36 decks)

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