Renal Diseases Flashcards
Most common nephrotic syndrome in kids
MCD
IF: granular pattern of immune complex deposition
LM: diffuse capillary thickening
Membranous Glomerulonephritis
IF: granular pattern of immune complex deposition
LM: hypercellular glomeruli
Acute PSGN
IF: linear pattern of immune complex deposition
Goodpasture’s syndrome
IF: deposition of IgG, IgM, IgA, and C3 in the mesangium
IgA nephropathy
Kimmelstiel-Wilson lesions (nodular glomerulosclerosis)
Diabetic glomerulonephropathy
Most common nephrotic syndrome in adults
Membranous glomerulonephritis
EM: loss of epithelial foot processes
MCD
Nephrotic syndrome a/w Hep B
Membranoproliferative glomerulonephritis
Nephrotic syndrome a/w HIV
Focal segmental glomerulosclerosis
Anti-GBM antibodies, hematuria, hemoptysis
Goodpasture’s
EM: subendothelial humps and tram-track appearance
Membranoproliferative glomerulonephritis
Nephritis, deafness, cataracts
Alport syndrome
LM: crescent formation in the glomeruli
Rapidly progressive glomerulonephritis
LM: segmental sclerosis and hyalinosis
FSGS
Purpura on back of arms and legs, abdominal pain, IgA nephropathy
Henoch-Schonlein purpura
LM: wire loop appearance
SLE nephropathy
apple-green birefringence with Congo-red stain under polarized light
Renal Amyloidosis
EM: spiking of the GBM due to electron dense subepithelial desposits
Membranous glomerulonephritis
RBC casts
Acute glomerulonephritis
WBC casts (2)
Acute pyelonephritis
Acute interstitial nephritis
Bacterial cast
Acute pyelonephritis
Epithelial cell cast
Renal tubule damage
Waxy cast
chronic renal failure (stasis of urine flow)
Fatty cast
Nephrotic syndrome
Granular cast
Acute tubular necrosis
Multiple mesangial nodules
Kimmelsteil Wilson lesions, indicates diabetic glomerulonephropathy
Nephrotic syndrome and hearing loss
Alport’s Syndrome
4 year-old with facial edema and proteinuria: treatment
Steroids
