Neuro Pharm

Question 1

Endogenous agonist for mu receptor

Answer 1

Morphine

Question 2

Endogenous agonist for delta receptor

Answer 2

encaplin

Question 3

Endogenous agonist for kappa receptor

Answer 3

thynorphin

Question 4

Opioid cough suppressant commonly used with the expectorant guaifenisin

Answer 4

dextromethorphan

Question 5

Opioid used in the treatment of diarrhea

Answer 5

Loperamide/diphenoxylate

Question 6

Opioid commonly used in the treatment of acute heart failure

Answer 6

morphine

Question 7

Opioid receptor antagonist

Answer 7

naloxone/naltrexone

Question 8

Nonaddictive weak opioid agonist

Answer 8

tramadol

Question 9

Partial opioid agonist that causes less respiratory depression

Answer 9

butorphenol

Question 10

5 drug classes used to treat glaucoma

Answer 10

alpha agonists
beta blockers
cholinomimetics
diuretics (acetazolamide and mannitol)
prostaglandins

Question 11

What drugs are known for causing Steven’s Johnson syndrome (4)?

Answer 11

seizure drugs, sulfonamides, -cillins, allopurinol

Question 12

How is barbiturate overdose managed?

Answer 12

symptomatically

Question 13

How is benzo overdose managed?

Answer 13

flumazenil

Question 14

IV anesthetic, a/w hallucinations and bad dreams

Answer 14

ketamine

Question 15

Inhaled, nephrotoxic anaesthetic

Answer 15

methoxyfluorane

Question 16

IV anaesthetic, most common drug for endoscopy

Answer 16

medazolam, with fentanyl

Question 17

Inhaled anesthetic, causes convulsions and seizures

Answer 17

enfluorane

Question 18

inhaled anesthetic, hepatotoxic

Answer 18

halothane

Question 19

IV anaesthetic, used for rapid anesthesia induction and short procedures

Answer 19

propafol

Question 20

inhaled, used for rapid anesthesia

Answer 20

nitric oxide

Question 21

IV anesthetic decreases cerebral flood flow

Answer 21

barbiturates (thiopental)

Question 22

IV anesthetic, does not induce histamine release like morphine

Answer 22

fentanyl

Question 23

high triglyceride content increases risk of pancreatitis with long-term use

Answer 23

propafol

Question 24

What agents are used in the treatment of Parkinson’s? (5)

Answer 24

Bromocriptine, pramoprexol, ropenorol, pergolide(dopamine agonists)
Amantadine, 
L-dopa with carbidopa (increase dopamine levels)
Selegiline, entacapone, tocapone (inhibit dopamine breakdown)
Antimuscarinic drugs (benztropine)

Question 25

What side effects are common to most anti-epileptics? (5)

Answer 25

diplopia, sedation, ataxiz, nystagmus, dizziness

Question 26

Toxic side effects of phenytoin (6)

Answer 26

hirsutism, gingival hyperplasia, fetal hydantoin syndrome, drug-induced lupus and Stephens Johnson syndrome, induces cytochrome p-450

Question 27

Mechanism of action of dantrolene

Answer 27

prevents release of Ca from sarcoplasmic reticulum of skeletal muscles

Question 28

Mechanism of action of local anesthetics

Answer 28

Block Na channels

Question 29

Which fibers are blocked first in local anesthesia?

Answer 29

Pain, small myelinated first, then small unmyelinated, large myelinated, large unmyelinated

Question 30

What drugs can be used to reverse neuromuscular blockade?

Answer 30

Neostigmine

Question 31

What is the mechanism of action of sumatriptan? For what populations is this drug contraindicated?

Answer 31

Serotonin 1B/1D agonist

Contraindicated in coronary artery disease, Prinz-Metals angina, pregnancy

Question 32

What is the mechanism of action of drugs used to treat Alzheimer’s disease?

Answer 32

Acetylcholinesterase inhibitors (rivastigmine, galantamine, donepazil)
NMDA receptor antagonist (Memantine)