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Step 1 stuff > Cancer Drugs: the cover-your-ass, bare bones version > Flashcards

Cancer Drugs: the cover-your-ass, bare bones version Flashcards

1
Q

Mechanism for etoposide

A

Forms complex between topoisomerase II and DNA

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2
Q

Mechanism for busulfan

A

alkylates DNA

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3
Q

Toxicity for busulfan

A

pulmonary fibrosis

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4
Q

Mechanism for bleomycin

A

fragments DNA

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5
Q

Toxicity for bleomycin

A

pulmonary fibrosis

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6
Q

Mechanism for 6-mercaptopurine

A

blocks purine synthesis

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7
Q

Metabolism of 6-mercaptopurine is accomplished by:

A

xanthine oxidase

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8
Q

Mechanism for cisplatin and carboplatin

A

cross-links DNA

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9
Q

Toxicity for cisplatin, carboplatin (2)

A

nephrotoxic, ototoxic

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10
Q

Mechanism for cyclophosphamide

A

Nitrogen mustard, alkylates DNA (electrophile that binds DNA)

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11
Q

Mechanism for methotrexate

A

Folic acid analog, inhibits dihydrofolate reductase

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12
Q

Mechanism for paclutaxol

A

Prevents tubulin disassembly

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13
Q

Mechanism for doxyrubicin and danirubicin

A

Intercalates DNA, produces oxygen free radicals

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14
Q

Toxicity for doxyrubicin and danirubicin

A

cardiotoxic

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15
Q

Mechanism for nitrosureas

A

DNA alkylating agents, used in brain cancer

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16
Q

Mechanism for vincristine and vinblastine

A

Prevents tubulin assembly

17
Q

Mechanism for 5-fluorouracil

A

Inhibits thymidylate synthase, leads to decreased nucleotide synthesis

18
Q

Mechanism for tomaxafen/rumoxifen

A

SERM: blocks estrogen binding to ER+ cells

19
Q

Mechanism for cytaravine (similar to…)

A

Inhibition of DNA polymerase: similar to acyclovir and foscarnet

20
Q

Mechanism for etoposide (similar to…)

A

Inhibition of topoisomerase II: similar to fluoroquinolones

21
Q

Mechanism for methotrexate (similar to…)

A

Folic acid analog, inhibits dihydrofolate reductase: similar to trimethoprim

22
Q

Mechanism for trastuzimab

A

Monoclonal antibody against HER-2

23
Q

Mechanism for bleomycin, oxyrubicin, danirubicin

A

Free radical induced DNA strand breakage

24
Q

Mechanism of 6-mercaptopurine

A

Inhibitor of PRPP synthetase

25
Q

Methotrexate: reversible by…

A

Leucovorin

26
Q

3 treatments for choriocarcinoma

A

methotrexate, vincristine, vinblastine

27
Q

Treatment for AML

A

cytarabine

28
Q

2 treatments for CML

A

Busulfan, amatanib

29
Q

Prevents breast cancer (2)

A

Tamoxifen, raloxifene

30
Q

3 treatments for testicular cancer

A

etoposide, bleomycin, cisplatin

31
Q

Topical treatment for AKs and basal cell cancers

A

5-fluorouracil

32
Q

Dactinomycin: use

A

childhood tumors (Ewing’s sarcoma, Wilm’s tumor, rhabdomyosarcoma)

33
Q

Mechanism of hydroxyurea

A

Inhibits ribonucleotide reductase

34
Q

Drug with side effect of hemorrhagic cystitis

A

cyclophosphamide

35
Q

Mechanism for imatinib

A

Antibody against Philadelphia chromosome

36
Q

Know 9 side effects of Prednisone

A 
Cushing-like symptoms
Immunosuppression
Cataracts
Acne
Osteoporosis
Hypertension
Peptic ulcers
hyperglycemia
Psychosis

Step 1 stuff (36 decks)

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