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Step 1 stuff > Antibiotics strictly mechanisms > Flashcards

Antibiotics strictly mechanisms Flashcards

1
Q

Chloramphenicol

A

Inhibits 50s peptidyltransferase

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2
Q

Isoniazid

A

decrease synthesis of mycolic acids

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3
Q

Ticarcillin, carbenicillin, pipericillin

A

Bind PBPs, inhibit transpeptidase cross-linking. Extended spectrum, antipseudomonal

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4
Q

Aztreonam

A

Inhibits cell wall synthesis, resistant to Beta-lactamases

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5
Q

Tetracyclines

A

Bind 30s subunit and prevent attachment of aminoacyl-tRNA

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6
Q

Sulfonamides

A

inhibits dihydropteroate synthetase

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7
Q

Poymyxins

A

Bind to cell membranes, disrupt osmotic properties

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8
Q

Imipenem/cilastatin, meropenem

A

broad-spectrum, beta-lactamase resistant carbapenem

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9
Q

Clindamycin

A

blocks peptide bond formation at 50s ribosomal subunit

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10
Q

Methicillin, nafcillin, dicloxaillin

A

Bind PBPs and block transpeptidase cross-linking, but penicillinase resistant due to bulkier R group

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11
Q

Trimethoprim

A

inhibits dihydrofolate reductase

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12
Q

Vancomycin

A

Binds D-ala D-ala portion of cell wall precursors to inhibit cell wall formation

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13
Q

Fluoroquinolones

A

Inhibit DNA gyrase (topo II)

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14
Q

Aminoglycosides

A

Bind 30s subunit, inhibit formation of initiation complex and cause misreading of mRNA in aerobes

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15
Q

Rifampin

A

inhibits DNA-dependent RNA polymerase

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16
Q

Cephalosporins

A

Beta lactams: inhibit cell wall synthesis but not susceptible to penicillinases

17
Q

Ampicillin, amoxicillin

A

Bind PBPs and block transpeptidase cross-linking of cell wall, wider spectrum than other penicillins, but penicillinase sensitive

18
Q

Metronidazole

A

Forms toxic metabolites in bacterial cell that damage DNA

19
Q

Macrolides

A

Bind to 23s rRNA of 50s subunit, block translocation

20
Q

Penicillin

A

Binds PBPs, blocks transpeptidase cross-linking of cell wall

Step 1 stuff (36 decks)

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