HAART Flashcards

0
Q

Protease inhibitors: mechanism

A

Block protease in progeny virions

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1
Q

-navirs: type

A

Protease inhibitor

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2
Q

Protease inhibitors: toxicities (4)

A

GI intolerance
Hyperglycemia
Lipodystrophy
Thrombocytopenia (indinavir)

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3
Q

Zidovudine: type

A

NRTI

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4
Q

Didanosine: type

A

NRTI

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5
Q

Zalcitabine: type

A

NRTI

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6
Q

Stavudine: type

A

NRTI

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7
Q

Lamivudine: type

A

NRTI

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8
Q

Abacavir: type

A

NRTI

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9
Q

Nevirapine: type

A

NNRTI

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10
Q

Etavirenz: type

A

NNRTI

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11
Q

Delavirdine: type

A

NNRTI

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12
Q

RTIs: mechanism

A

Preferentially inhibit reverse transcriptase of HIV, prevent incorporation of DNA copy of viral genome into host DNA

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13
Q

RTIs: toxicities (5)

A
Bone marrow suppression
Peripheral neuropathy
Lactic acidosis (NRTIs)
Rash (NNRTIs)
Megaloblastic anemia (ZDV)
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14
Q

Enfuvirtide: type

A

Fusion inhibitor

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15
Q

Enfuvirtide: mechanism

A

bind viral gp41 subunit, inhibit conformational change required for fusion with CD4 cells

16
Q

Enfuvirtide: toxicities (3)

A

hypersensitivity reactions
reactions at subcutaneous injection site
increased risk of bacterial pneumonia

17
Q

Enfuvirtide: clinical use

A

In patients who don’t respond to other antiretrovirals