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Step 1 stuff > Antibiotic mechanisms, uses > Flashcards

Antibiotic mechanisms, uses Flashcards

1
Q

Block cell wall synthesis by inhibiting peptidoglycan cross-linking (4)

A

-cillins, imipenem, aztreonam, cephalosporins

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2
Q

Block peptidoglycan synthesis (2)

A

bacitracin

vancomycin

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3
Q

Disrupt bacterial cell membranes

A

Polymixins

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4
Q

Block nucleotide synthesis (2)

A

Sulfonamides

Trimethoprim

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5
Q

Block DNA topoisomerases

A

Fluoroquinolones

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6
Q

Block mRNA synthesis

A

Rifampin

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7
Q

BLock protein synthesis at 50s ribosomal subunit (5)

A 
Chloramphenicol
Macrolides
Clindamycin
Streptogramins
Linezolid
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8
Q

Block protein synthesis at 30S ribosomal subunit (2)

A

Aminoglycosides

Tetracyclines

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9
Q

Penicillin: uses (4)

A

Gram positive cocci
Gram positive rods
gram negative cocci
Spirochetes

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10
Q

Penicillinase-resistant penicillins: use

A

Staph aureus (not MRSA)

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11
Q

Ampicillin, amoxicillin: uses (6)

A 
H influenza
E. coli
Listeria monocytogenes
Proteus mirabilis
Salmonella
enterococci
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12
Q

Ticarcillin, carbenicillin, piperacillin: use

A

gram - rods (pseudomonas)

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13
Q

1st gen cephalosporins: uses (3)

A

Proteus, E. Coli, Klebsiella

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14
Q

2nd gen cephalosporins: uses (7)

A

H influenza, Enterobacter aerogenes, Neisseria, Proteus mirabilis, E. Coli, Klebsiella, Serratia marcescens

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15
Q

3rd gen cephalosporins: use

A

serious, beta-lactam resistant gram negatives

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16
Q

4th gen: uses (2)

A

Pseudomonas, gram-positive organisms

17
Q

Tetracyclines: use

A 
V cholerae
Acne
Chlamydia
Ureaplasma
Urealyticum
M pneumonia
Tularemia
H pylori
Borrelia burgdorferi
Rickettsia
18
Q

Vancomycin: use

A

serious, gram+ multidrug resistant organisms

19
Q

Aminoglycosides: use

A

severe g- rods, use with beta lactams

20
Q

Chloramphenicol: use

A

meningitis

21
Q

Fluoroquinolones: main uses (2)

A

UTIs, GI infections

22
Q

Metronidazole: uses (6)

A

Giardia
Entamoeba
Trichomonas

Gardnerella vaginalis
Anaerobes,
h Pylori

23
Q

Isoniazid: use

A

mycoplasma tuberculosis prophylaxis

24
Q

Isoniazid: mechanism

A

decreased synthesis of mycolid acids

25
Q

Rifampin: mechanism

A

Inhibits DNA-dependent RNA polymerase

Step 1 stuff (36 decks)

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