Immunosuppressants Flashcards
1
Q
Precursor of 6-mercaptopurine
A
Azathioprene
2
Q
May prevent nephrotoxicity with mannitol diuresis
A
cyclosporine
3
Q
Antibody that binds to CD3 on T cells
A
murominab
4
Q
Antibody that binds to IL-2 receptor on activated T cells
A
daclizumab
5
Q
Inhibits inosine monophosphate dehydrogenase
A
mycophenylate
6
Q
Inhibits calcineurin, leading to loss of IL-2 production, leading to blockage of T cell differentiation and activation
A
cyclosporine
7
Q
binds FK-binding protein, leads to loss of IL-2 production
A
tacrolimus
8
Q
binds FKBP-12, leads to inhibition of mTOR, leads to inhibition of T cell proliferation
A
cerolimus
9
Q
used for lupus nephritis
A
mycophenylate
10
Q
Metabolized by xanthine oxidase, therefore allopurinol increases its toxicity
A
azathioprene
