Toxicities

Question 1

Atropine-like CV effects (3)

Answer 1

TCAs
low potency neuroleptics
first generation antihistamines

Question 2

Coronary vasospasm (2)

Answer 2

Cocaine

Sumatriptan

Question 3

Cutaneous flushing (4)

Answer 3

Vancomycin
Adenosine
Niacin
Ca channel blockers

Question 4

Dilated cardiomyopathy

Answer 4

Doxorubicin, daunorubicin

Question 5

Torsades de pointes (9)

Answer 5

Class III (sotalol), class Ia (quinidine, antiarrhythmics
Cisapide
Macrolides
Haloperidol/risperidone
Chloroquine
Methaloquine
Methadone
Protease inhibitors

Question 6

Agranulocytosis (6)

Answer 6

Clozapine
Carbamazepine
Colchicine
Propylthiouracil
Methimazole
Dapsone

Question 7

Aplastic anemia (5)

Answer 7

Chloramphenicol
Benzene
NSAIDs
Propylthiouracil
Methimazole

Question 8

Direct Coombs-positive hemolytic anemia

Answer 8

Methyldopa

Question 9

Gray baby syndrome

Answer 9

Chloramphenicol

Question 10

Hemolysis in G6PD deficient patients (6)

Answer 10

Isoniazid
Sulfonamides

Primaquine
Aspirin
Ibuprofen
Nitrofurantoin

Question 11

Megaloblastic anemia (3)

Answer 11

Phenytoin
Methotrexate
Sulfa drugs

Question 12

Thrombotic complicaitons

Answer 12

OCPs

Question 13

Cough

Answer 13

ACE inhibitors

Question 14

Pulmonary fibrosis (3)

Answer 14

BLeomycin
Amiodarone
Busulfan

Question 15

Acute cholestatic hepatitis

Answer 15

Macrolides

Question 16

Focal to massive hepatic necrosis (4)

Answer 16

Halothane
Valproic acid
Acetaminophen
Amanita phalloides

Question 17

Hepatitis

Answer 17

INH

Question 18

Pseudomembranous colitis (2)

Answer 18

Clindamycin
Ampicillin
(really, any antibiotic)

Question 19

Adrenocortical insufficiency

Answer 19

Glucocorticoid withdrawal (HPA suppression)

Question 20

Gynecomastia (7)

Answer 20

Spironolactone
Digitalis
Cimetidine
Alcohol
Ketaconazole
estrogens
marijuana

Question 21

Hot flashes (2)

Answer 21

Tamoxifen

Clomiphene

Question 22

Hypothyroidism (2)

Answer 22

Lithium

Amiodarone

Question 23

Gingival hyperplasia

Answer 23

Phenytoin

Question 24

Gout (2)

Answer 24

Furosemide

Thiazides

Question 25

Osteoporosis (2)

Answer 25

Corticosteroids | Heparin

Question 26

Photosensitivity (3)

Answer 26

Sulfonamides Amiodarone Tetracycline

Question 27

Rash (Stevens-Johnson syndrome) (12)

Answer 27

``` Ethosuximide Lamotrigine Carbamazepine Phenobarbital Phenytoin Sulfa drugs Penicillin Allopurinol Penicillin seizure meds sulfa drugs ```

Question 28

SLE-like syndrome (5)

Answer 28

``` Hydralazine INH Procainamide Phenytoin Sulfonamide ```

Question 29

Tendonitis, tendon rupture, cartilage damage

Answer 29

Fluoroquinolones

Question 30

Fanconi's syndrome (3)

Answer 30

Expired tetracycline Heavy metals Wilson's disease

Question 31

Interstitial nephritis (3)

Answer 31

Methicillin NSAIDs Furosemide

Question 32

Hemorrhagic cystitis (2)

Answer 32

Cyclophosphamide | Ifosfamide

Question 33

Nephrotoxicity (2)

Answer 33

Cyclosporine | Tacrolimus

Question 34

Cinchonism (dizziness, headache, tinnitus) (2)

Answer 34

Quinidine | Quinine

Question 35

Diabetes insipidus (2)

Answer 35

Lithium Demeclocycline (treat with amiloride and hydrochlorothiazide)

Question 36

Parkinson-like syndrome (5)

Answer 36

``` Haloperidol Chlorpromazine Reserpine Metoclopramide MPTP (illegal demorol) ```

Question 37

Seizures (5)

Answer 37

``` Bupropion Imipenem/cilastatin Isoniazid Evening primrose oil Enfluorane ```

Question 38

Tardive dyskinesia

Answer 38

Typical antipsychotics

Question 39

Disulfiram-like reaction (5)

Answer 39

``` Metronidazole Cephalosporins Procarbazine First generation sulfonylureas Disulfyram ```

Question 40

Nephrotoxicity/Neurotoxicity

Answer 40

Polymyxins

Question 41

Nephrotoxicity/ototoxicity (4)

Answer 41

Aminoglycosides Vancomycin Loop diuretics Cisplatin

Question 42

P-450 Inducers (8)

Answer 42

``` Quinidine (Queen) Barbiturates (Barb) St. John's wort (Steals) Phenytoin (Phen-phen) Rifampin (and refuses) Griseofulvin (greasy) Carbamazepine (carbs) Chronic alcohol use (chronically) ```

Question 43

P-450 inhibitors (8)

Answer 43

``` Sulfonamides Isoniazid Cimetidine Ketoconazole Erythromycin Grapefruit juice Acute alcohol use Protease inhibitors ```