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Toxicities Flashcards

1
Q

Atropine-like CV effects (3)

A

TCAs
low potency neuroleptics
first generation antihistamines

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2
Q

Coronary vasospasm (2)

A

Cocaine

Sumatriptan

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3
Q

Cutaneous flushing (4)

A

Vancomycin
Adenosine
Niacin
Ca channel blockers

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4
Q

Dilated cardiomyopathy

A

Doxorubicin, daunorubicin

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5
Q

Torsades de pointes (9)

A 
Class III (sotalol), class Ia (quinidine, antiarrhythmics
Cisapide
Macrolides
Haloperidol/risperidone
Chloroquine
Methaloquine
Methadone
Protease inhibitors
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6
Q

Agranulocytosis (6)

A 
Clozapine
Carbamazepine
Colchicine
Propylthiouracil
Methimazole
Dapsone
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7
Q

Aplastic anemia (5)

A 
Chloramphenicol
Benzene
NSAIDs
Propylthiouracil
Methimazole
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8
Q

Direct Coombs-positive hemolytic anemia

A

Methyldopa

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9
Q

Gray baby syndrome

A

Chloramphenicol

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10
Q

Hemolysis in G6PD deficient patients (6)

A

Isoniazid
Sulfonamides

Primaquine
Aspirin
Ibuprofen
Nitrofurantoin

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11
Q

Megaloblastic anemia (3)

A

Phenytoin
Methotrexate
Sulfa drugs

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12
Q

Thrombotic complicaitons

A

OCPs

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13
Q

Cough

A

ACE inhibitors

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14
Q

Pulmonary fibrosis (3)

A

BLeomycin
Amiodarone
Busulfan

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15
Q

Acute cholestatic hepatitis

A

Macrolides

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16
Q

Focal to massive hepatic necrosis (4)

A

Halothane
Valproic acid
Acetaminophen
Amanita phalloides

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17
Q

Hepatitis

A

INH

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18
Q

Pseudomembranous colitis (2)

A

Clindamycin
Ampicillin
(really, any antibiotic)

19
Q

Adrenocortical insufficiency

A

Glucocorticoid withdrawal (HPA suppression)

20
Q

Gynecomastia (7)

A 
Spironolactone
Digitalis
Cimetidine
Alcohol
Ketaconazole
estrogens
marijuana
21
Q

Hot flashes (2)

A

Tamoxifen

Clomiphene

22
Q

Hypothyroidism (2)

A

Lithium

Amiodarone

23
Q

Gingival hyperplasia

24
Q

Gout (2)

A

Furosemide

Thiazides

25
Q

Osteoporosis (2)

A

Corticosteroids

Heparin

26
Q

Photosensitivity (3)

A

Sulfonamides
Amiodarone
Tetracycline

27
Q

Rash (Stevens-Johnson syndrome) (12)

A 
Ethosuximide
Lamotrigine
Carbamazepine
Phenobarbital
Phenytoin
Sulfa drugs
Penicillin
Allopurinol
Penicillin
seizure meds
sulfa drugs
28
Q

SLE-like syndrome (5)

A 
Hydralazine
INH
Procainamide
Phenytoin
Sulfonamide
29
Q

Tendonitis, tendon rupture, cartilage damage

A

Fluoroquinolones

30
Q

Fanconi’s syndrome (3)

A

Expired tetracycline
Heavy metals
Wilson’s disease

31
Q

Interstitial nephritis (3)

A

Methicillin
NSAIDs
Furosemide

32
Q

Hemorrhagic cystitis (2)

A

Cyclophosphamide

Ifosfamide

33
Q

Nephrotoxicity (2)

A

Cyclosporine

Tacrolimus

34
Q

Cinchonism (dizziness, headache, tinnitus) (2)

A

Quinidine

Quinine

35
Q

Diabetes insipidus (2)

A

Lithium
Demeclocycline
(treat with amiloride and hydrochlorothiazide)

36
Q

Parkinson-like syndrome (5)

A 
Haloperidol
Chlorpromazine
Reserpine
Metoclopramide
MPTP (illegal demorol)
37
Q

Seizures (5)

A 
Bupropion
Imipenem/cilastatin
Isoniazid
Evening primrose oil
Enfluorane
38
Q

Tardive dyskinesia

A

Typical antipsychotics

39
Q

Disulfiram-like reaction (5)

A 
Metronidazole
Cephalosporins
Procarbazine
First generation sulfonylureas
Disulfyram
40
Q

Nephrotoxicity/Neurotoxicity

A

Polymyxins

41
Q

Nephrotoxicity/ototoxicity (4)

A

Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin

42
Q

P-450 Inducers (8)

A 
Quinidine (Queen)
Barbiturates (Barb)
St. John's wort (Steals)
Phenytoin (Phen-phen)
Rifampin (and refuses)
Griseofulvin (greasy)
Carbamazepine (carbs)
Chronic alcohol use (chronically)
43
Q

P-450 inhibitors (8)

A 
Sulfonamides
Isoniazid
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice
Acute alcohol use
Protease inhibitors

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